3.A.1.204.18
Brown. Part of a membrane-spanning permease system necessary for the transport
of pigment precursors into pigment cells responsible for eye color.
Brown and white (TC# 3.A.1.204.1) dimerize for the transport of guanine (Campbell and Nash 2001). Knockouts of brown in the noctuid moth, Helicoverpa armigera, show no phenotypic effects on viability or
pigmentation (Khan et al. 2017).
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| Accession Number: | P12428 |
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| Protein Name: | Protein brown |
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| Length: | 675 |
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| Molecular Weight: | 75943.00 |
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| Species: | Drosophila melanogaster (Fruit fly) [7227] |
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| Number of TMSs: | 7 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
guanine |
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1: MQESGGSSGQ GGPSLCLEWK QLNYYVPDQE QSNYSFWNEC RKKRELRILQ DASGHMKTGD
61: LIAILGGSGA GKTTLLAAIS QRLRGNLTGD VVLNGMAMER HQMTRISSFL PQFEINVKTF
121: TAYEHLYFMS HFKMHRRTTK AEKRQRVADL LLAVGLRDAA HTRIQQLSGG ERKRLSLAEE
181: LITDPIFLFC DEPTTGLDSF SAYSVIKTLR HLCTRRRIAK HSLNQVYGED SFETPSGESS
241: ASGSGSKSIE MEVVAESHES LLQTMRELPA LGVLSNSPNG THKKAAICSI HQPTSDIFEL
301: FTHIILMDGG RIVYQGRTEQ AAKFFTDLGY ELPLNCNPAD FYLKTLADKE GKENAGAVLR
361: AKYEHETDGL YSGSWLLARS YSGDYLKHVQ NFKKIRWIYQ VYLLMVRFMT EDLRNIRSGL
421: IAFGFFMITA VTLSLMYSGI GGLTQRTVQD VGGSIFMLSN EMIFTFSYGV TYIFPAALPI
481: IRREVGEGTY SLSAYYVALV LSFVPVAFFK GYVFLSVIYA SIYYTRGFLL YLSMGFLMSL
541: SAVAAVGYGV FLSSLFESDK MASECAAPFD LIFLIFGGTY MNVDTVPGLK YLSLFFYSNE
601: ALMYKFWIDI DNIDCPVNED HPCIKTGVEV LQQGSYRNAD YTYWLDCFSL VVVAVIFHIV
661: SFGLVRRYIH RSGYY