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3.A.1.204.6 The efflux porter for phosphatidylcholine and its analogues as well as toxic alkyl phospholipids, ABCG4 (Castanys-Munoz et al., 2007). Also promotes cholesterol efflux to the mature forms of HDL (HDL2 and HDL3) (Voloshyna and Reiss, 2011).
Accession Number:	A4HWI7
Protein Name:	ABCG4
Length:	741
Molecular Weight:	83045.00
Species:	Leishmania infantum [5671]
Number of TMSs:	5
Location¹ / Topology² / Orientation³:	Membrane¹ / Multi-pass membrane protein²
Substrate	1,2-diacyl-sn-glycero-3-phosphocholine(1+), cholesterol, ether lipid

RefSeq:	XP_001464428.1
Entrez Gene ID:	5067821
Pfam:	PF01061 PF00005
Gene Ontology GO:0016020 C:membrane GO:0005524 F:ATP binding GO:0016887 F:ATPase activity
References (1) [1] “Comparative genomic analysis of three Leishmania species that cause diverse human disease.” Peacock C.S.et.al. 17572675

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MGTQVDQAHK PSVGTPTELT SIPPTASVTP PQAKSNAEDA KVPALSRAVN FTWENLTYQV 
61:	PVEDKDGNVI YKTLLFNLSG CAKGGRVLAI MGPSGAGKTT LMGTITGKLF NATARQEGCC 
121:	FMNNNIYQQR YKRLVSYVCQ DDIVMGKDTP REAIYFSARL RLGLDSETAR RRVADVIKRL 
181:	SLTKCQDTIL GIPGILKGVS GGERKRANIG TELVTNPFVM LLDEPTTGLD SVNAVRVGHL 
241:	LQDLAKNDMR TVIATVHSPS SELFDLFDDL LLLAKGHVIY HGPTADSIEY FASLGYDVPP 
301:	RTNPTEYFMN LLQLPEEILS QLWLAWEDYV MSDAANDNPC LTPVTGVITL TDDYLEEQLE 
361:	LKGANFCLQF SELFKRSWRM YLRDPGNFYG RSVQTLFFAI FVGLFFFNLQ LNQQGVQDRL 
421:	GALYVTLMNN LFGAAMNGIA AFPPERAVFL QEQANDAYNA YTYFLAKNLA ELPWQILFPT 
481:	VFDLIAYFMI HFHRSAGAFF VHWFILVLLA NLGYSFGLMF ATFFKQSQAA FAMVPLILLP 
541:	LFIVAGLFAN TDRLYPYWEW LNYISFPRHA YLGVFTNEFE RLTVICDPVT PLCTFPDGQA 
601:	VIEYMGFQGW HYWQTFVALI VYQIGLRFIG ATSLYYQGRQ RRGKLQFVKN LRKRVASPRA 
661:	IASARSNDEL SDVQSTLVGS IATPSNAYGT GVSSPINNPE NHQPIWDGES ERATLALPDT 
721:	PVTYVESPVD VKDMKPRKYR S

3.A.1.204.6
The efflux porter for phosphatidylcholine and its analogues as well as toxic alkyl phospholipids, ABCG4 (Castanys-Munoz et al., 2007). Also promotes cholesterol efflux to the mature forms of HDL (HDL2 and HDL3) (Voloshyna and Reiss, 2011).

Cross database links:

Gene Ontology

References (1)

External Searches:

Analyze:

3.A.1.204.6The efflux porter for phosphatidylcholine and its analogues as well as toxic alkyl phospholipids, ABCG4 (Castanys-Munoz et al., 2007). Also promotes cholesterol efflux to the mature forms of HDL (HDL2 and HDL3) (Voloshyna and Reiss, 2011).

Cross database links:

Gene Ontology

References (1)

External Searches:

Analyze:

3.A.1.204.6
The efflux porter for phosphatidylcholine and its analogues as well as toxic alkyl phospholipids, ABCG4 (Castanys-Munoz et al., 2007). Also promotes cholesterol efflux to the mature forms of HDL (HDL2 and HDL3) (Voloshyna and Reiss, 2011).