3.A.1.205.24
Multidrug resistance (MDR) exporter, (Np)AbcG5/PDR5 of 1498 aas and 12 TMSs. NpABCG5/NpPDR5 is barely expressed in leaf tissues under normal
conditions, but its expression is induced by the biotic stress hormone
methyl jasmonate, or when tissues are wounded or chewed by an insect. NpABCG5/NpPDR5 confers resistance to the
herbivore Manduca sexta (Toussaint et al. 2017). The same system, ABCG5 of soybean plays a role in iron homeoistasis and the iron deficiency response (Wang et al. 2023).
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| Accession Number: | I6XGC6 |
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| Protein Name: | Pleiotropic drug resistance transporter 5 |
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| Length: | 1498 |
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| Molecular Weight: | 169614.00 |
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| Species: | Nicotiana plumbaginifolia (Leadwort-leaved tobacco) [4092] |
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| Number of TMSs: | 15 |
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| Substrate |
iron cation, drug |
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1: MEANGGPRRL GSSRSSMSRT MSRSRSRASW NVEDVFNPMP SRRSTRGEED EEALTWAALE
61: KLPTYDRLRK TVLKSVMESE NNQGNKKVVH KEVDVRNLGM NERQEFIDRV FRVAEEDNEK
121: FMRKFRNRID KVGITLPTVE VRYEHLTIEA DCYIGDRALP TLPNAARNIA ESALSCVGIT
181: LAEKTKLTIL KDASGIIKPS RMTLLLGPPS SGKTTLLLAL AGKLDPTLKV RGEITYNGHG
241: LKEFVPQKTS AYISQNDVHV AEMTVKETLD FSARCQGVGS RYELLTELAR RERDAGIFPE
301: AEIDLFMKAT AMEGVESSLI TDYTLRILGL DVCRDTIVGD EMIRGISGGQ KKRVTTGEMI
361: VGPTKTLFTD EISTGLDSST TFQIVKCLQQ IVHLTEATVL MSLLQPAPET FDLFDDIILL
421: SEGQIVYQGP REHVLEFFET CGFRCPERKG TADFLQEVTS RKDQEQYWAN RHRPYQYISV
481: TEFAKRFKRF HVGLRIENEL SVPYDKTRSH PAALIFKKYT VPILELLKTN FDKEWLLIKR
541: NSFVYVFKTV QIIIVALIGS TVFLRTKMHT NTVDDGAIYV GALLFGMVIN MFNGFSELAM
601: IIQRLPVFYK HRDLLFHPPW TFTLPTVLLK VPISVFETIV WMVMTYYTIG YAPEASRFFK
661: QSLLTFLIQQ MAAGLFRLTA GVCRTMIIAN TGGALMLLLI FLLCGFILPR GSIPDWWRWG
721: YWVSPLSYGF NAFTVNEMFA PRWMNKFGPD GTTRLGLQVM KNFDVFTERR WFWIGAAALL
781: GFTILFNVLF TLVLVYLSPL NKPQATLSKE QASDMEADQE ESTGSPRLRI SQSKRDDLPR
841: SLSAADGNKT REMEIRRMSS RTSSSGFYRN EDANLEAANG VAAKKGMILP FTPLAMSFDD
901: VSYFVDMPPE MKDQGVTEDK LQLLREVTGA FRPGVLTALM GVSGAGKTTL MDVLAGRKTG
961: GYIEGDVRIS GFPKNQETFA RVSGYCEQTD IHSPQVTIHE SLIFSAFLRL PKEVSKEDKM
1021: IFVDEVMDLV ELDNLKDAIV GLPGVTGLST EQRKRLTIAV ELVANPSIIF MDEPTSGLDA
1081: RAAAIVMRTV RNTVDTGRTV VCTIHQPSID IFEAFDELLL MKRGGQVIYA GPLGRHSQKI
1141: IEYFEAIPGV QKIKEKYNPA TWMLEASSIG TEARLGMDFA EYYRSSALHQ RNKALVKELS
1201: APPPGAKDLY FTTQFSQPAW GQFKSCLWKQ WWTYWRSPDY NLVRFFFSLA AALLIGTIFW
1261: NVGSKRKSSG DLMTVIGAMY AAVLFVGINN CSTVQPIVAV ERTVFYRERA AGMYSALPYA
1321: MAQVFAEIPY ILVQTTYYTL IIYAMVGFEW TAAKFFWFYF VTFFSFLYWT YYGMMTVSIT
1381: PNHQVAAIFA AAFYALFNLF SGFFIPRPRI PKWWIWYYWI CPVAWTVYGS IVSQYGDVED
1441: TIQVPGVFPN PRIKDYIKDH FGYSSDFMAP VAVVLVGFAA FFAFMYAYAI KTLNFQTR