3.A.1.205.29
ABCG37 (PDR9; PDR12, ETA4, PIS1) of 1450 aas and 12 TMSs in a CMCM domain arrangement where each M domain contains 6 TMSs. It confers resistance to auxinic herbicides (Ito and Gray 2006) and contributes oxygenated coumarins to root exudates (Ziegler et al. 2017). It responds to abiotic stresses such as heavy metals (Cd2+ and lead) and is regulated by pathogenic defense hormones (Kim et al. 2007). It probably exports a wide range of compounds including monolignols (Lefèvre and Boutry 2018) and Indole butyric acid (IBA), a precursor of indole acetic acid (IAA) (Damodaran and Strader 2019). Fe deficiency induces the secretion of coumarin compounds by Arabidopsis roots, and the ABCG37 ABC transporter is required for this secretion; these compounds improved plant Fe nutrition (Fourcroy et al. 2014).
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| Accession Number: | Q9LFH0 |
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| Protein Name: | ABC transporter G family member 37 |
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| Length: | 1450 |
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| Molecular Weight: | 164106.00 |
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| Species: | Arabidopsis thaliana (Mouse-ear cress) [3702] |
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| Number of TMSs: | 12 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
cadmium(2+), coumarins, indole-3-butyric acid |
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1: MAHMVGADDI ESLRVELAEI GRSIRSSFRR HTSSFRSSSS IYEVENDGDV NDHDAEYALQ
61: WAEIERLPTV KRMRSTLLDD GDESMTEKGR RVVDVTKLGA VERHLMIEKL IKHIENDNLK
121: LLKKIRRRID RVGMELPTIE VRYESLKVVA ECEVVEGKAL PTLWNTAKRV LSELVKLTGA
181: KTHEAKINII NDVNGIIKPG RLTLLLGPPS CGKTTLLKAL SGNLENNLKC SGEISYNGHR
241: LDEFVPQKTS AYISQYDLHI AEMTVRETVD FSARCQGVGS RTDIMMEVSK REKEKGIIPD
301: TEVDAYMKAI SVEGLQRSLQ TDYILKILGL DICAEILIGD VMRRGISGGQ KKRLTTAEMI
361: VGPTKALFMD EITNGLDSST AFQIVKSLQQ FAHISSATVL VSLLQPAPES YDLFDDIMLM
421: AKGRIVYHGP RGEVLNFFED CGFRCPERKG VADFLQEVIS KKDQAQYWWH EDLPYSFVSV
481: EMLSKKFKDL SIGKKIEDTL SKPYDRSKSH KDALSFSVYS LPNWELFIAC ISREYLLMKR
541: NYFVYIFKTA QLVMAAFITM TVFIRTRMGI DIIHGNSYMS ALFFALIILL VDGFPELSMT
601: AQRLAVFYKQ KQLCFYPAWA YAIPATVLKV PLSFFESLVW TCLSYYVIGY TPEASRFFKQ
661: FILLFAVHFT SISMFRCLAA IFQTVVASIT AGSFGILFTF VFAGFVIPPP SMPAWLKWGF
721: WANPLSYGEI GLSVNEFLAP RWNQMQPNNF TLGRTILQTR GMDYNGYMYW VSLCALLGFT
781: VLFNIIFTLA LTFLKSPTSS RAMISQDKLS ELQGTEKSTE DSSVRKKTTD SPVKTEEEDK
841: MVLPFKPLTV TFQDLNYFVD MPVEMRDQGY DQKKLQLLSD ITGAFRPGIL TALMGVSGAG
901: KTTLLDVLAG RKTSGYIEGD IRISGFPKVQ ETFARVSGYC EQTDIHSPNI TVEESVIYSA
961: WLRLAPEIDA TTKTKFVKQV LETIELDEIK DSLVGVTGVS GLSTEQRKRL TIAVELVANP
1021: SIIFMDEPTT GLDARAAAIV MRAVKNVADT GRTIVCTIHQ PSIDIFEAFD ELVLLKRGGR
1081: MIYTGPLGQH SRHIIEYFES VPEIPKIKDN HNPATWMLDV SSQSVEIELG VDFAKIYHDS
1141: ALYKRNSELV KQLSQPDSGS SDIQFKRTFA QSWWGQFKSI LWKMNLSYWR SPSYNLMRMM
1201: HTLVSSLIFG ALFWKQGQNL DTQQSMFTVF GAIYGLVLFL GINNCASALQ YFETERNVMY
1261: RERFAGMYSA TAYALGQVVT EIPYIFIQAA EFVIVTYPMI GFYPSAYKVF WSLYSMFCSL
1321: LTFNYLAMFL VSITPNFMVA AILQSLFYVG FNLFSGFLIP QTQVPGWWIW LYYLTPTSWT
1381: LNGFISSQYG DIHEEINVFG QSTTVARFLK DYFGFHHDLL AVTAVVQIAF PIALASMFAF
1441: FVGKLNFQRR