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| Accession Number: | Q8X0Z3 |
| Protein Name: | CNAFR1 aka CDR1 aka AFR1 |
| Length: | 1543 |
| Molecular Weight: | 172627.00 |
| Species: | Cryptococcus neoformans (Filobasidiella neoformans) [5207] |
| Number of TMSs: | 14 |
| Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
| Substrate | 1H-pyrrole, fluconazole |
Cross database links:
| Pfam: | PF01061 PF00005 PF06422 |
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Gene Ontology
GO:0016021
C:integral to membrane
GO:0005524
F:ATP binding
GO:0042626
F:ATPase activity, coupled to transmembrane m...
GO:0006810
P:transport
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References (1)[1] “Identification and characterization of a Cryptococcus neoformans ATP binding cassette (ABC) transporter-encoding gene, CnAFR1, involved in the resistance to fluconazole.” Posteraro B.et.al. 12519188
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MSATGVPAEL NNLGAPITAT TQNPSGLANS QVTSGPASSA TQHDEHRSSA GNTLADEEND 61: KAVESEKAEV IDAAADGKQK RLAADSSENI VTELEPHHVS IHRGKEEFAA LERRYSTLSQ 121: QSQHELHRPT TRHSVRSSFS RKDRVVSRLT QDDAEKAKEG EGEFNLVDVL RSGRENQDEA 181: GIKRKAVGVI WEDLEVIGAG GMRINIRNFS SAIIEQFMMP AFKILSIFGV NPFAPKPKAI 241: LHPSSGLLKP GEMCLVLGRP GAGCTTFLKT ITNQRAGFME IKGNVEYAGV GWKEMRKRYG 301: GEVVYNQEDD DHLPTLTVAQ TIRFAPATKT PKKKIPGVSA KQFQDDMLDL LLSMLNIKHT 361: ANTIVGNAYV RGVSGGERKR VSIAEMFCSG ATVCSWDNST RGLDASTALD YAKSLRLLTD 421: IMGQTTFVSL YQAGEGIYDQ FDKVLVLNEG HVAYFGPAKE ARQYMIGLGY RDLPRQTTAD 481: YLSGCTDVNE RRFADGRDET NVPATPEEMD KAYKESEVCA RMTREREEYK QLMAEDATAR 541: EDFRQAVLEQ KHKGVSKKSP YTVSFLQQVF IIFKRQLRLK FQDHFGISTG YATAIISALI 601: VGSVYFRLPE TASGAFTRGG LLFLGLLFNA LTSFSELPSQ MLGRSVLYRQ NEYRFYRPAA 661: FALAAVLADV PYNASVIFLF SIVLYFMGGL YSSGGAFFMF FLFVFLTFMV MSAFFRTLGV 721: ATSDYNVAAR LASVLISFMV TYTGYMIPVQ RMKRWLFWIF YLNPLSYGYE AIFANEFSRI 781: NLTCDSSYTI PRNIPEAGIT GYPDTLGPNQ MCSIFGSTPG DPNVSGSDYM ATGYSYYKAH 841: IWRNFGILLG FFAFFMFLQM LFIEVLEQGA KHFSINVYKK EDKDLKAKNE RLAERLEAFR 901: AGELEQDLSE LKMRPEPFTW EVLNYTVPVP GGHRQLLNDI YGYVKPGSLT ALMGASGAGK 961: TTVLDVRASR KNIGVIEGDV LMNGRPIGTG FQRGCGYAEQ QDTHEWTTTV REALRYSAYL 1021: RQPQHVPKQE KDDYVEDIIE LLELQELADA MIGFPGYGLS VEARKRVTIG VELAAKPELL 1081: LFLDEPTSGL DGQSAYNIVR FLKKLCAAGQ KILCTIHQPN ALLFQSFDRL LLLQRGGECV 1141: YFGDIGPDSK VLIDYLERNG AKVPHDANPA EFMLEAIGAG SRKRIGSDWG EKWRNSPEFA 1201: EVKREIQELK AEALAKPVEE KSNRTEYATS FFFQLKTVLR RTNVALWRNA DYQWTRLFAH 1261: LAIGLIVTLT FLQLDNSVQS LQYRVFAIFF ATVLPALILA QIEPQYIMSR MTFNREASSK 1321: MYSSTVFALT QLLSEMPYSL GCAVSFFLLL YYGVGFPYAS SRAGYFFLMI LVTEVYAVTL 1381: GQAVAALSPT ILIAALFNPF LLVLFSIFCG VTAPPPTLPY FWRKWMWPLD PFTRLISGLV 1441: STVLQDQEVV CKDGEYQVFP APSGQTCQQW AGAFAEAIGG YINNPDSTGD CQFCQYRTGQ 1501: AFFTPLEISF STRWRDFGIF ICYVVFNILV LLIAARFLKW QRR