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| Accession Number: | Q9XIE2 |
| Protein Name: | Pleiotropic drug resistance protein 8 aka PDR8 |
| Length: | 1469 |
| Molecular Weight: | 165082.00 |
| Species: | Arabidopsis thaliana (Mouse-ear cress) [3702] |
| Number of TMSs: | 15 |
| Location1 / Topology2 / Orientation3: | Cell membrane1 / Multi-pass membrane protein2 |
| Substrate | cadmium(2+), lead(2+), quercetin, glucosinolate, phytoalexin, salicylate, salicylate |
Cross database links:
| RefSeq: | NP_176196.1 |
|---|---|
| Entrez Gene ID: | 842281 |
| Pfam: | PF01061 PF00005 PF08370 |
| KEGG: | ath:AT1G59870 |
Gene Ontology
GO:0009941
C:chloroplast envelope
GO:0016021
C:integral to membrane
GO:0005739
C:mitochondrion
GO:0005886
C:plasma membrane
GO:0005524
F:ATP binding
GO:0016887
F:ATPase activity
GO:0015086
F:cadmium ion transmembrane transporter activity
GO:0015691
P:cadmium ion transport
GO:0052544
P:callose deposition in cell wall during defe...
GO:0042742
P:defense response to bacterium
GO:0009817
P:defense response to fungus, incompatible in...
GO:0042344
P:indole glucosinolate catabolic process
GO:0031348
P:negative regulation of defense response
GO:0009627
P:systemic acquired resistance
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References (17)[1] “Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.” Theologis A.et.al. 11130712 [2] “Empirical analysis of transcriptional activity in the Arabidopsis genome.” Yamada K.et.al. 14593172 [3] “The plant PDR family of ABC transporters.” van den Brule S.et.al. 12430018 [4] “Phosphoproteomics of the Arabidopsis plasma membrane and a new phosphorylation site database.” Nuehse T.S.et.al. 15308754 [5] “Organization and function of the plant pleiotropic drug resistance ABC transporter family.” Crouzet J.et.al. 16506311 [6] “Conserved requirement for a plant host cell protein in powdery mildew pathogenesis.” Consonni C.et.al. 16732289 [7] “Arabidopsis PEN3/PDR8, an ATP binding cassette transporter, contributes to nonhost resistance to inappropriate pathogens that enter by direct penetration.” Stein M.et.al. 16473969 [8] “Loss of AtPDR8, a plasma membrane ABC transporter of Arabidopsis thaliana, causes hypersensitive cell death upon pathogen infection.” Kobae Y.et.al. 16415066 [9] “Mapping the Arabidopsis organelle proteome.” Dunkley T.P.J.et.al. 16618929 [10] “Temporal analysis of sucrose-induced phosphorylation changes in plasma membrane proteins of Arabidopsis.” Niittylae T.et.al. 17586839 [11] “Quantitative phosphoproteomics of early elicitor signaling in Arabidopsis.” Benschop J.J.et.al. 17317660 [12] “The ABC transporter AtPDR8 is a cadmium extrusion pump conferring heavy metal resistance.” Kim D.-Y.et.al. 17355438 [13] “Quantitative phosphoproteomic analysis of plasma membrane proteins reveals regulatory mechanisms of plant innate immune responses.” Nuehse T.S.et.al. 17651370 | |
External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MDYNPNLPPL GGGGVSMRRS ISRSVSRASR NIEDIFSSGS RRTQSVNDDE EALKWAAIEK 61: LPTYSRLRTT LMNAVVEDDV YGNQLMSKEV DVTKLDGEDR QKFIDMVFKV AEQDNERILT 121: KLRNRIDRVG IKLPTVEVRY EHLTIKADCY TGNRSLPTLL NVVRNMGESA LGMIGIQFAK 181: KAQLTILKDI SGVIKPGRMT LLLGPPSSGK TTLLLALAGK LDKSLQVSGD ITYNGYQLDE 241: FVPRKTSAYI SQNDLHVGIM TVKETLDFSA RCQGVGTRYD LLNELARREK DAGIFPEADV 301: DLFMKASAAQ GVKNSLVTDY TLKILGLDIC KDTIVGDDMM RGISGGQKKR VTTGEMIVGP 361: TKTLFMDEIS TGLDSSTTFQ IVKCLQQIVH LNEATVLMSL LQPAPETFDL FDDIILVSEG 421: QIVYQGPRDN ILEFFESFGF KCPERKGTAD FLQEVTSKKD QEQYWVNPNR PYHYIPVSEF 481: ASRYKSFHVG TKMSNELAVP FDKSRGHKAA LVFDKYSVSK RELLKSCWDK EWLLMQRNAF 541: FYVFKTVQIV IIAAITSTLF LRTEMNTRNE GDANLYIGAL LFGMIINMFN GFAEMAMMVS 601: RLPVFYKQRD LLFYPSWTFS LPTFLLGIPS SILESTAWMV VTYYSIGFAP DASRFFKQFL 661: LVFLIQQMAA SLFRLIASVC RTMMIANTGG ALTLLLVFLL GGFLLPKGKI PDWWGWAYWV 721: SPLTYAFNGL VVNEMFAPRW MNKMASSNST IKLGTMVLNT WDVYHQKNWY WISVGALLCF 781: TALFNILFTL ALTYLNPLGK KAGLLPEEEN EDADQGKDPM RRSLSTADGN RRGEVAMGRM 841: SRDSAAEASG GAGNKKGMVL PFTPLAMSFD DVKYFVDMPG EMRDQGVTET RLQLLKGVTG 901: AFRPGVLTAL MGVSGAGKTT LMDVLAGRKT GGYIEGDVRI SGFPKVQETF ARISGYCEQT 961: DIHSPQVTVR ESLIFSAFLR LPKEVGKDEK MMFVDQVMEL VELDSLRDSI VGLPGVTGLS 1021: TEQRKRLTIA VELVANPSII FMDEPTSGLD ARAAAIVMRA VRNTVDTGRT VVCTIHQPSI 1081: DIFEAFDELM LMKRGGQVIY AGPLGQNSHK VVEYFESFPG VSKIPEKYNP ATWMLEASSL 1141: AAELKLSVDF AELYNQSALH QRNKALVKEL SVPPAGASDL YFATQFSQNT WGQFKSCLWK 1201: QWWTYWRSPD YNLVRFIFTL ATSLLIGTVF WQIGGNRSNA GDLTMVIGAL YAAIIFVGIN 1261: NCSTVQPMVA VERTVFYRER AAGMYSAMPY AISQVTCELP YVLIQTVYYS LIVYAMVGFE 1321: WKAEKFFWFV FVSYFSFLYW TYYGMMTVSL TPNQQVASIF ASAFYGIFNL FSGFFIPRPK 1381: IPKWWIWYYW ICPVAWTVYG LIVSQYGDVE TRIQVLGGAP DLTVKQYIED HYGFQSDFMG 1441: PVAAVLIAFT VFFAFIFAFC IRTLNFQTR