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3.A.1.208.1
Multi-drug resistance-associated protein, MRP1-like protein (MLP1 or MRP1) (Exporter of leukotrienes, glutathione, methotrexate and cysteinyl conjugates of organic anions, drugs, unmodified hydrophobic xenobiotics and hydrophilic conjugated endobiotics). Vincristine and glutathione are co-transported. MRP1 catalyzes export of glutathione during apoptosis (Hammond et al., 2007). Also transports reduced folates as well as mono-, di- and tri-glutamate derivatives of folic acid and methotrexate (Assaraf et al., 2006; Nigam 2015). The ABCC subgoup of ABC exporters consists of 13 members in mammals, ABCC1 to 13, and their expression levels correlate either positively or negatively (depeding on the system) with gastric cancer (Mao et al. 2019). The ABCC subfamily may be involved in the transmembrane transport of organic selenium (Se) (Li et al. 2023). Suppression of MRP1 activity by coumarin derivatives has been documented (Shahpouri et al. 2023).  Overexpression of MDR1 protects against cardiotoxicity by augmenting doxorubicin efflux from cardiomyocytes (Kok et al. 2024).

Accession Number:O88269
Protein Name:MRP6 aka MRP1 aka MLP1 aka ABCC6
Length:1502
Molecular Weight:164995.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate glutathione, folic acid, methotrexate, vincristine, leukotriene, drug

Cross database links:

RefSeq: NP_112275.1   
Entrez Gene ID: 81642   
Pfam: PF00664    PF00005   
KEGG: rno:81642   

Gene Ontology

GO:0016324 C:apical plasma membrane
GO:0016021 C:integral to membrane
GO:0016328 C:lateral plasma membrane
GO:0005624 C:membrane fraction
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane m...
GO:0006200 P:ATP catabolic process
GO:0055085 P:transmembrane transport

References (2)

[1] “Hepatic expression of multidrug resistance-associated protein-like proteins maintained in eisai hyperbilirubinemic rats.”  Hirohashi T.et.al.   9614210
[2] “Transport function and hepatocellular localization of mrp6 in rat liver.”  Madon J.et.al.   10692506

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MNGEHSMATP GESCAGLRVW NQTEQEPVAY HLLNLCFLRA AGSWVPPMYL WVLGPIYLLY 
61:	IHRHGCCYLR MSRLFKIKMV LGFALILLYT FNAAVPLWRI HRGMPQAPEL LIHPTVWLTT 
121:	MSFATFLIHM ERKKGVRASG LLFGYWLLCC LVPAIDTVQQ ASAGSFRQEP LHHLATYLCL 
181:	SLVVAELVLS CLVDQPPFFS EDSKPLNPCP EAEASFPSKA MFWWASGLLW KGYRKLLGPK 
241:	DLWSLERENS SEELVSQLER EWRRNFSELP GHKGHSGMGT PETEAFLQPE RSQRGPLLRA 
301:	IWRVFRSTFL LGTLSLVISD AFRFAVPKLL SLFLEFMGDL ESSAWTGWLL AVLMFLSACL 
361:	QTLFEQQYMY RVKVLQMRLR TAITGLVYRK VLVLSSGSRK SSAAGDVVNL VSVDVQRLVE 
421:	SILHLNGLWL LFLWIIVCFV YLWQLLGPSA LTAVAVFLSL LPLNFFITKK RSFHQEEQMR 
481:	QKASRARLTS SMLRTVRTIK SHGWECAFLE RLLHIRGQEL GALKTSAFLF SVSLVSFQVS 
541:	TFLVALVVFA VHTLVAEDNA MDAEKAFVTL TVLSILNKAQ AFLPFSVHCL VQARVSFDRL 
601:	AAFLCLEEVD PNGMVLSPSR CSSKDRISIH NGTFAWSQES PPCLHGINLT VPQGCLLAVV 
661:	GPVGAGKSSL LSALLGELLK VEGSVSIEGS VAYVPQEAWV QNTSVVENVC FRQELDLPWL 
721:	QEVLEACALG SDVASFPAGV HTPVGEQGMN LSGGQKQRLS LARAVYRRAA VYLMDDPLAA 
781:	LDAHVSQEVF KQVIGPSGLL QGTTRILVTH TLHVLPQADQ ILVLANGTIA EMGSYQDLLH 
841:	RNGALVGLLD GARQPAGEGE GEAHAAATSD DLGGFSGGGT PTRRPERPRP SDAAPVKGST 
901:	SEAQMEPSLD DVEVTGLTAG EDSVQYGRVK SATYLSYLRA VGTPLCTYTL FLFLCQQVAS 
961:	FCQGYWLSLW ADDPVVDGKQ MHSALRGSIF GLLGCLQAIG LFASMAAVFL GGARASCLLF 
1021:	RSLLWDVARS PIGFFERTPV GNLLNRFSKE TDIVDVDIPD KMRTLLTYAF GLLEVGLAVS 
1081:	MATPLAIVAI LPLMLLYAGF QSLYVATCCQ LRRLESASYS SVCSHLAETF QGSQVVRAFQ 
1141:	AQGPFTAQHD ALMDENQRIS FPRLVADRWL AANLELLGNG LVFVAATCAV LSKAHLSAGL 
1201:	AGFSVSAALQ VTQTLQWVVR SWTDLENSMV AVERVQDYVH TPKEAPWRLP SSAAQPLWPC 
1261:	GGQIEFRDFG LRHRPELPMA VQGVSLKIHA GEKVGIVGRT GAGKSSLTWG LLRLQEATEG 
1321:	GIWIDGVPIT DMGLHTLRSR ITIIPQDPVL FPGSLRMNLD LLQENTDEGI WAALETVQLK 
1381:	AFVTSLPGQL QYECSGQGDD LSVGQKQLLC LARALLRKTQ ILILDEATAS VDPGTEIQMQ 
1441:	AALERWFAQC TVLLIAHRLR SVMNCARVLV MDEGQVAESG SPAQLLAQKG LFYRLAQESG 
1501:	LA