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|---|---|
| Accession Number: | P39109 |
| Protein Name: | YCFI aka YCF1 aka YDR135C aka YD9302.11C |
| Length: | 1515 |
| Molecular Weight: | 171121.00 |
| Species: | Saccharomyces cerevisiae (Baker's yeast) [4932] |
| Number of TMSs: | 14 |
| Location1 / Topology2 / Orientation3: | Vacuole membrane1 / Multi-pass membrane protein2 |
| Substrate | metal cation, arsenite(3-), glutathione, selenodiglutathione(2-), diazaborine derivative, drug |
Cross database links:
| DIP: | DIP-2612N |
|---|---|
| RefSeq: | NP_010419.1 |
| Entrez Gene ID: | 851713 |
| Pfam: | PF00664 PF00005 |
| KEGG: | sce:YDR135C |
Gene Ontology
GO:0016021
C:integral to membrane
GO:0005774
C:vacuolar membrane
GO:0005524
F:ATP binding
GO:0015127
F:bilirubin transmembrane transporter activity
GO:0015431
F:glutathione S-conjugate-exporting ATPase ac...
GO:0005515
F:protein binding
GO:0015723
P:bilirubin transport
GO:0046686
P:response to cadmium ion
GO:0042493
P:response to drug
GO:0055085
P:transmembrane transport
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References (12)[1] “A yeast metal resistance protein similar to human cystic fibrosis transmembrane conductance regulator (CFTR) and multidrug resistance-associated protein.” Szczypka M.S.et.al. 7521334 [2] “The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.” Jacq C.et.al. 9169867 [3] “The yeast cadmium factor protein (YCF1) is a vacuolar glutathione S-conjugate pump.” Li Z.S.et.al. 8626454 [4] “The products of YCF1 and YLL015w (BPT1) cooperate for the ATP-dependent vacuolar transport of unconjugated bilirubin in Saccharomyces cerevisiae.” Petrovic S.et.al. 10790694 [5] “Global analysis of protein expression in yeast.” Ghaemmaghami S.et.al. 14562106 [6] “A proteomics approach to understanding protein ubiquitination.” Peng J.et.al. 12872131 [7] “Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.” Gruhler A.et.al. 15665377 [8] “A global topology map of the Saccharomyces cerevisiae membrane proteome.” Kim H.et.al. 16847258 | |
External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MAGNLVSWAC KLCRSPEGFG PISFYGDFTQ CFIDGVILNL SAIFMITFGI RDLVNLCKKK 61: HSGIKYRRNW IIVSRMALVL LEIAFVSLAS LNISKEEAEN FTIVSQYAST MLSLFVALAL 121: HWIEYDRSVV ANTVLLFYWL FETFGNFAKL INILIRHTYE GIWYSGQTGF ILTLFQVITC 181: ASILLLEALP KKPLMPHQHI HQTLTRRKPN PYDSANIFSR ITFSWMSGLM KTGYEKYLVE 241: ADLYKLPRNF SSEELSQKLE KNWENELKQK SNPSLSWAIC RTFGSKMLLA AFFKAIHDVL 301: AFTQPQLLRI LIKFVTDYNS ERQDDHSSLQ GFENNHPQKL PIVRGFLIAF AMFLVGFTQT 361: SVLHQYFLNV FNTGMYIKSA LTALIYQKSL VLSNEASGLS STGDIVNLMS VDVQKLQDLT 421: QWLNLIWSGP FQIIICLYSL YKLLGNSMWV GVIILVIMMP LNSFLMRIQK KLQKSQMKYK 481: DERTRVISEI LNNIKSLKLY AWEKPYREKL EEVRNNKELK NLTKLGCYMA VTSFQFNIVP 541: FLVSCCTFAV FVYTEDRALT TDLVFPALTL FNLLSFPLMI IPMVLNSFIE ASVSIGRLFT 601: FFTNEELQPD SVQRLPKVKN IGDVAINIGD DATFLWQRKP EYKVALKNIN FQAKKGNLTC 661: IVGKVGSGKT ALLSCMLGDL FRVKGFATVH GSVAYVSQVP WIMNGTVKEN ILFGHRYDAE 721: FYEKTIKACA LTIDLAILMD GDKTLVGEKG ISLSGGQKAR LSLARAVYAR ADTYLLDDPL 781: AAVDEHVARH LIEHVLGPNG LLHTKTKVLA TNKVSALSIA DSIALLDNGE ITQQGTYDEI 841: TKDADSPLWK LLNNYGKKNN GKSNEFGDSS ESSVRESSIP VEGELEQLQK LNDLDFGNSD 901: AISLRRASDA TLGSIDFGDD ENIAKREHRE QGKVKWNIYL EYAKACNPKS VCVFILFIVI 961: SMFLSVMGNV WLKHWSEVNS RYGSNPNAAR YLAIYFALGI GSALATLIQT IVLWVFCTIH 1021: ASKYLHNLMT NSVLRAPMTF FETTPIGRIL NRFSNDIYKV DALLGRTFSQ FFVNAVKVTF 1081: TITVICATTW QFIFIIIPLS VFYIYYQQYY LRTSRELRRL DSITRSPIYS HFQETLGGLA 1141: TVRGYSQQKR FSHINQCRID NNMSAFYPSI NANRWLAYRL ELIGSIIILG AATLSVFRLK 1201: QGTLTAGMVG LSLSYALQIT QTLNWIVRMT VEVETNIVSV ERIKEYADLK SEAPLIVEGH 1261: RPPKEWPSQG DIKFNNYSTR YRPELDLVLK HINIHIKPNE KVGIVGRTGA GKSSLTLALF 1321: RMIEASEGNI VIDNIAINEI GLYDLRHKLS IIPQDSQVFE GTVRENIDPI NQYTDEAIWR 1381: ALELSHLKEH VLSMSNDGLD AQLTEGGGNL SVGQRQLLCL ARAMLVPSKI LVLDEATAAV 1441: DVETDKVVQE TIRTAFKDRT ILTIAHRLNT IMDSDRIIVL DNGKVAEFDS PGQLLSDNKS 1501: LFYSLCMEAG LVNEN