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| Accession Number: | Q9C8G9 |
| Protein Name: | Multidrug resistance-associated protein 1 |
| Length: | 1622 |
| Molecular Weight: | 181927.00 |
| Species: | Arabidopsis thaliana (Mouse-ear cress) [3702] |
| Number of TMSs: | 15 |
| Location1 / Topology2 / Orientation3: | Vacuole membrane1 / Multi-pass membrane protein2 |
| Substrate | cadmium(2+), mercury(2+), organic anion, folic acid, methotrexate, glutathione conjugate, Isobutylshikonin, antifolate |
Cross database links:
| RefSeq: | NP_001031116.1 NP_174329.1 |
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| Entrez Gene ID: | 839920 |
| Pfam: | PF00664 PF00005 |
| KEGG: | ath:AT1G30400 |
Gene Ontology
GO:0016021
C:integral to membrane
GO:0000325
C:plant-type vacuole
GO:0005886
C:plasma membrane
GO:0005774
C:vacuolar membrane
GO:0005524
F:ATP binding
GO:0005516
F:calmodulin binding
GO:0008559
F:xenobiotic-transporting ATPase activity
GO:0055085
P:transmembrane transport
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References (13)[1] “AtMRP1 gene of Arabidopsis encodes a glutathione S-conjugate pump: isolation and functional definition of a plant ATP-binding cassette transporter gene.” Lu Y.-P.et.al. 9223346 [2] “Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.” Theologis A.et.al. 11130712 [3] “Empirical analysis of transcriptional activity in the Arabidopsis genome.” Yamada K.et.al. 14593172 [4] “Differential expression of genes coding for ABC transporters after treatment of Arabidopsis thaliana with xenobiotics.” Tommasini R.et.al. 9271206 [5] “Cloning and expression analyses of the AtMRP4, a novel MRP-like gene from Arabidopsis thaliana.” Sanchez-Fernandez R.et.al. 9671034 [6] “AtMRP2, an Arabidopsis ATP-binding cassette transporter able to transport glutathione S-conjugates and chlorophyll catabolites: functional comparisons with AtMRP1.” Lu Y.-P.et.al. 9490749 [7] “The Arabidopsis thaliana ABC protein superfamily, a complete inventory.” Sanchez-Fernandez R.et.al. 11346655 [8] “Multifunctionality of plant ABC transporters -- more than just detoxifiers.” Martinoia E.et.al. 11855639 [9] “Family business: the multidrug-resistance related protein (MRP) ABC transporter genes in Arabidopsis thaliana.” Kolukisaoglu U.H.et.al. 12430019 | |
External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MGFEPLDWYC KPVPNGVWTK TVDYAFGAYT PCAIDSFVLG ISHLVLLILC LYRLWLITKD 61: HKVDKFCLRS KWFSYFLALL AAYATAEPLF RLVMRISVLD LDGAGFPPYE AFMLVLEAFA 121: WGSALVMTVV ETKTYIHELR WYVRFAVIYA LVGDMVLLNL VLSVKEYYGS FKLYLYISEV 181: AVQVAFGTLL FVYFPNLDPY PGYTPVGTEN SEDYEYEELP GGENICPERH ANLFDSIFFS 241: WLNPLMTLGS KRPLTEKDVW HLDTWDKTET LMRSFQKSWD KELEKPKPWL LRALNNSLGG 301: RFWWGGFWKI GNDCSQFVGP LLLNELLKSM QLNEPAWIGY IYAISIFVGV VLGVLCEAQY 361: FQNVMRVGYR LRSALIAAVF RKSLRLTNEG RKKFQTGKIT NLMTTDAESL QQICQSLHTM 421: WSAPFRIIVA LVLLYQQLGV ASIIGALFLV LMFPIQTVII SKTQKLTKEG LQRTDKRIGL 481: MNEVLAAMDT VKCYAWENSF QSKVQTVRDD ELSWFRKAQL LSAFNMFILN SIPVLVTVVS 541: FGVFSLLGGD LTPARAFTSL SLFSVLRFPL FMLPNIITQM VNANVSLNRL EEVLSTEERV 601: LLPNPPIEPG QPAISIRNGY FSWDSKADRP TLSNINLDIP LGSLVAVVGS TGEGKTSLIS 661: AMLGELPARS DATVTLRGSV AYVPQVSWIF NATVRDNILF GAPFDQEKYE RVIDVTALQH 721: DLELLPGGDL TEIGERGVNI SGGQKQRVSM ARAVYSNSDV CILDDPLSAL DAHVGQQVFE 781: KCIKRELGQT TRVLVTNQLH FLSQVDKILL VHEGTVKEEG TYEELCHSGP LFQRLMENAG 841: KVEDYSEENG EAEVDQTSVK PVENGNANNL QKDGIETKNS KEGNSVLVKR EERETGVVSW 901: KVLERYQNAL GGAWVVMMLV ICYVLTQVFR VSSSTWLSEW TDSGTPKTHG PLFYNIVYAL 961: LSFGQVSVTL INSYWLIMSS LYAAKKMHDA MLGSILRAPM VFFQTNPLGR IINRFAKDMG 1021: DIDRTVAVFV NMFMGSIAQL LSTVILIGIV STLSLWAIMP LLVVFYGAYL YYQNTSREIK 1081: RMDSTTRSPV YAQFGEALNG LSSIRAYKAY DRMAEINGRS MDNNIRFTLV NMAANRWLGI 1141: RLEVLGGLMV WLTASLAVMQ NGKAANQQAY ASTMGLLLSY ALSITSSLTA VLRLASLAEN 1201: SLNSVERVGN YIEIPSEAPL VIENNRPPPG WPSSGSIKFE DVVLRYRPEL PPVLHGVSFL 1261: ISPMDKVGIV GRTGAGKSSL LNALFRIVEL EKGRILIDEC DIGRFGLMDL RKVLGIIPQA 1321: PVLFSGTVRF NLDPFSEHND ADLWESLERA HLKDTIRRNP LGLDAEVTEA GENFSVGQRQ 1381: LLSLARALLR RSKILVLDEA TAAVDVRTDV LIQKTIREEF KSCTMLIIAH RLNTIIDCDK 1441: VLVLDSGKVQ EFSSPENLLS NGESSFSKMV QSTGTANAEY LRSITLENKR TREANGDDSQ 1501: PLEGQRKWQA SSRWAAAAQF ALAVSLTSSH NDLQSLEIED DNSILKKTKD AVVTLRSVLE 1561: GKHDKEIEDS LNQSDISRER WWPSLYKMVE GLAVMSRLAR NRMQHPDYNL EGKSFDWDNV 1621: EM