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3.A.1.208.21
The thale cress protein atMRP5 (atABCC5), a high-affinity inositol hexakisphosphate transporter; involved in guard cell signaling and phytate storage (Nagy et al., 2009). Transports organic anions and phytate (Lefèvre and Boutry 2018). In humans, activities of lysosomal ABCC3, ABCC5 and ABCC10 are responsible for lysosomal sequestration of doxorubicin and paclitaxel-oregongreen488 in paclitaxel-resistant cancer cell lines (Gronkowska et al. 2023).

Accession Number:Q7GB25
Protein Name:ABC transporter C family member 5
Length:1514
Molecular Weight:168574.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:17
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate organic anion, myo-inositol hexakisphosphate, myo-inositol hexakisphosphate

Cross database links:

RefSeq: NP_171908.1   
Entrez Gene ID: 839277   
Pfam: PF00664    PF00005   
KEGG: ath:AT1G04120   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0000325 C:plant-type vacuole
GO:0005886 C:plasma membrane
GO:0005774 C:vacuolar membrane
GO:0005524 F:ATP binding
GO:0008281 F:sulfonylurea receptor activity
GO:0008559 F:xenobiotic-transporting ATPase activity
GO:0030007 P:cellular potassium ion homeostasis
GO:0009651 P:response to salt stress
GO:0055085 P:transmembrane transport

References (8)

[1] “Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.”  Theologis A.et.al.   11130712
[2] “The Arabidopsis thaliana ABC transporter AtMRP5 controls root development and stomata movement.”  Gaedeke N.et.al.   11296221
[3] “The Arabidopsis thaliana ABC protein superfamily, a complete inventory.”  Sanchez-Fernandez R.et.al.   11346655
[4] “Multifunctionality of plant ABC transporters -- more than just detoxifiers.”  Martinoia E.et.al.   11855639
[5] “Family business: the multidrug-resistance related protein (MRP) ABC transporter genes in Arabidopsis thaliana.”  Kolukisaoglu U.H.et.al.   12430019
[6] “The plant multidrug resistance ABC transporter AtMRP5 is involved in guard cell hormonal signalling and water use.”  Klein M.et.al.   12943546
[7] “Binding of sulfonylurea by AtMRP5, an Arabidopsis multidrug resistance-related protein that functions in salt tolerance.”  Lee E.K.et.al.   14684837
[8] “Plant ABC proteins - a unified nomenclature and updated inventory.”  Verrier P.J.et.al.   18299247

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDFIEISLIF REHLPLLELC SVIINLLLFL VFLFAVSARQ ILVCVRRGRD RLSKDDTVSA 
61:	SNLSLEREVN HVSVGFGFNL SLLCCLYVLG VQVLVLVYDG VKVRREVSDW FVLCFPASQS 
121:	LAWFVLSFLV LHLKYKSSEK LPFLVRIWWF LAFSICLCTM YVDGRRLAIE GWSRCSSHVV 
181:	ANLAVTPALG FLCFLAWRGV SGIQVTRSSS DLQEPLLVEE EAACLKVTPY STAGLVSLIT 
241:	LSWLDPLLSA GSKRPLELKD IPLLAPRDRA KSSYKVLKSN WKRCKSENPS KPPSLARAIM 
301:	KSFWKEAACN AVFAGLNTLV SYVGPYLISY FVDYLGGKEI FPHEGYVLAG IFFTSKLIET 
361:	VTTRQWYMGV DILGMHVRSA LTAMVYRKGL KLSSIAKQNH TSGEIVNYMA VDVQRIGDYS 
421:	WYLHDIWMLP MQIVLALAIL YKSVGIAAVA TLVATIISIL VTIPLAKVQE DYQDKLMTAK 
481:	DERMRKTSEC LRNMRVLKLQ AWEDRYRVRL EEMREEEYGW LRKALYSQAF VTFIFWSSPI 
541:	FVAAVTFATS IFLGTQLTAG GVLSALATFR ILQEPLRNFP DLVSMMAQTK VSLDRISGFL 
601:	QEEELQEDAT VVIPRGLSNI AIEIKDGVFC WDPFSSRPTL SGIQMKVEKG MRVAVCGTVG 
661:	SGKSSFISCI LGEIPKISGE VRICGTTGYV SQSAWIQSGN IEENILFGSP MEKTKYKNVI 
721:	QACSLKKDIE LFSHGDQTII GERGINLSGG QKQRVQLARA LYQDADIYLL DDPFSALDAH 
781:	TGSDLFRDYI LSALAEKTVV FVTHQVEFLP AADLILVLKE GRIIQSGKYD DLLQAGTDFK 
841:	ALVSAHHEAI EAMDIPSPSS EDSDENPIRD SLVLHNPKSD VFENDIETLA KEVQEGGSAS 
901:	DLKAIKEKKK KAKRSRKKQL VQEEERVKGK VSMKVYLSYM GAAYKGALIP LIILAQAAFQ 
961:	FLQIASNWWM AWANPQTEGD ESKVDPTLLL IVYTALAFGS SVFIFVRAAL VATFGLAAAQ 
1021:	KLFLNMLRSV FRAPMSFFDS TPAGRILNRV SIDQSVVDLD IPFRLGGFAS TTIQLCGIVA 
1081:	VMTNVTWQVF LLVVPVAVAC FWMQKYYMAS SRELVRIVSI QKSPIIHLFG ESIAGAATIR 
1141:	GFGQEKRFIK RNLYLLDCFV RPFFCSIAAI EWLCLRMELL STLVFAFCMV LLVSFPHGTI 
1201:	DPSMAGLAVT YGLNLNGRLS RWILSFCKLE NKIISIERIY QYSQIVGEAP AIIEDFRPPS 
1261:	SWPATGTIEL VDVKVRYAEN LPTVLHGVSC VFPGGKKIGI VGRTGSGKST LIQALFRLIE 
1321:	PTAGKITIDN IDISQIGLHD LRSRLGIIPQ DPTLFEGTIR ANLDPLEEHS DDKIWEALDK 
1381:	SQLGDVVRGK DLKLDSPVLE NGDNWSVGQR QLVSLGRALL KQAKILVLDE ATASVDTATD 
1441:	NLIQKIIRTE FEDCTVCTIA HRIPTVIDSD LVLVLSDGRV AEFDTPARLL EDKSSMFLKL 
1501:	VTEYSSRSTG IPEL