3.A.1.208.29
Multidrug resistance-associated protein 9, MRP9 of 1359 aas. Also called ABCC12. Expressed in testis, but widely expressed in other tissues at low levels. Isoform 5 is specifically expressed in brain, testis and breast cancer cells.
|
| Accession Number: | Q96J65 |
|---|
| Protein Name: | Multidrug resistance-associated protein 9 |
|---|
| Length: | 1359 |
|---|
| Molecular Weight: | 152297.00 |
|---|
| Species: | Homo sapiens (Human) [9606] |
|---|
| Number of TMSs: | 11 |
|---|
| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
|---|
| Substrate |
drug |
|---|
1: MVGEGPYLIS DLDQRGRRRS FAERYDPSLK TMIPVRPCAR LAPNPVDDAG LLSFATFSWL
61: TPVMVKGYRQ RLTVDTLPPL STYDSSDTNA KRFRVLWDEE VARVGPEKAS LSHVVWKFQR
121: TRVLMDIVAN ILCIIMAAIG PVILIHQILQ QTERTSGKVW VGIGLCIALF ATEFTKVFFW
181: ALAWAINYRT AIRLKVALST LVFENLVSFK TLTHISVGEV LNILSSDSYS LFEAALFCPL
241: PATIPILMVF CAAYAFFILG PTALIGISVY VIFIPVQMFM AKLNSAFRRS AILVTDKRVQ
301: TMNEFLTCIR LIKMYAWEKS FTNTIQDIRR RERKLLEKAG FVQSGNSALA PIVSTIAIVL
361: TLSCHILLRR KLTAPVAFSV IAMFNVMKFS IAILPFSIKA MAEANVSLRR MKKILIDKSP
421: PSYITQPEDP DTVLLLANAT LTWEHEASRK STPKKLQNQK RHLCKKQRSE AYSERSPPAK
481: GATGPEEQSD SLKSVLHSIS FVVRKGKILG ICGNVGSGKS SLLAALLGQM QLQKGVVAVN
541: GTLAYVSQQA WIFHGNVREN ILFGEKYDHQ RYQHTVRVCG LQKDLSNLPY GDLTEIGERG
601: LNLSGGQRQR ISLARAVYSD RQLYLLDDPL SAVDAHVGKH VFEECIKKTL RGKTVVLVTH
661: QLQFLESCDE VILLEDGEIC EKGTHKELME ERGRYAKLIH NLRGLQFKDP EHLYNAAMVE
721: AFKESPAERE EDAGIIVLAP GNEKDEGKES ETGSEFVDTK VPEHQLIQTE SPQEGTVTWK
781: TYHTYIKASG GYLLSLFTVF LFLLMIGSAA FSNWWLGLWL DKGSRMTCGP QGNRTMCEVG
841: AVLADIGQHV YQWVYTASMV FMLVFGVTKG FVFTKTTLMA SSSLHDTVFD KILKSPMSFF
901: DTTPTGRLMN RFSKDMDELD VRLPFHAENF LQQFFMVVFI LVILAAVFPA VLLVVASLAV
961: GFFILLRIFH RGVQELKKVE NVSRSPWFTH ITSSMQGLGI IHAYGKKESC ITYHLLYFNC
1021: ALRWFALRMD VLMNILTFTV ALLVTLSFSS ISTSSKGLSL SYIIQLSGLL QVCVRTGTET
1081: QAKFTSVELL REYISTCVPE CTHPLKVGTC PKDWPSRGEI TFRDYQMRYR DNTPLVLDSL
1141: NLNIQSGQTV GIVGRTGSGK SSLGMALFRL VEPASGTIFI DEVDICILSL EDLRTKLTVI
1201: PQDPVLFVGT VRYNLDPFES HTDEMLWQVL ERTFMRDTIM KLPEKLQAEV TENGENFSVG
1261: ERQLLCVARA LLRNSKIILL DEATASMDSK TDTLVQNTIK DAFKGCTVLT IAHRLNTVLN
1321: CDHVLVMENG KVIEFDKPEV LAEKPDSAFA MLLAAEVRL