3.A.1.208.33
Multidrug resistance export pump, ABCC or MRP1 of 1822 aas (González-Pons et al. 2009). It exports multiple drugs and glutathione conjugates.
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| Accession Number: | A7XLD3 |
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| Protein Name: | MRP |
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| Length: | 1822 |
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| Molecular Weight: | 214403.00 |
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| Species: | Plasmodium falciparum [5833] |
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| Number of TMSs: | 12 |
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| Substrate |
glutathione conjugate, drug |
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1: MTTYKENVGI SNKGNKKKKS CQNISFLNFL SFDWIRPLIN DLIKGDIQEL PNICRNFDVP
61: YYASKLEENL RDIEVEDSEF YSEKNSSNEH VLHHCNSNDA SEKKVYNVYY HNILWSILKT
121: FKFRIILIIS FYILETLIVT LGGKFIDYYM RILEGQKIPV YISFLKDFKV FSGLVVVMIM
181: FFHLFFEALL YFYFHLFTIN LKVSLMYFLY KINLCSNNNH LQNPDAFYNT YRKFSSQTEI
241: DEISRDFLSI GKNASSSSSG IKNNNKNIDN NKFVENDYII NFIKSTKKME KDSLNENRSL
301: PNVNIYNIMF SDVPSVTFFV TSCINLFNVF VKIFMSFYVF HIKIGSNSVG IAIWLSIALY
361: SAMILFEFLP SLFKSKYLIY RDKRIDNMHH VLKEFKLIKM FNWESFAFKY INIFRMKEMK
421: YCKIRLYLSN IGVFISAISS DIVEVVIFFI YLKDRLNKKE EIKFTSIIMP LYVYKILISN
481: VANFPNLVNN VMEGIVNIKR LNNYINDHLY YNDIKNYFMY RTRYNEDYNI VVDKTFLQNE
541: NITSHDDGTS HNLKHLKNVI KNKLTNMFKY FFFYHKMNYH KNIINKQILS GLLKNVDDNT
601: NKKICFQEHK SNSTYNYNSS HIHEKKEEYE NIHNSSNSTM SNEFKEKKKN NEYIIKLENC
661: SFGLSYDNKC DNDHILKNIN FNLKRNSLAI IIGNVGSGKS AFFHSILGDF NMTHGNLYIE
721: NFFKKMPILY VPQNSWLFMG NIRSMILFGN EYNPLIYKYT ILQSELLNDL STIEHGDMKY
781: INDDHNLSKG QKVRICLARA LYEHYIHMHK LCTDYEKKLI QPNEILDKDL INNKNISSYN
841: NKKSKLVNYN IPFNENYLQK CLMDDNNFYL YLLDDVFTSL DPSISKKIFS NLFCKEDNIS
901: FKDNCSFIIS MNKSTLDNFL IEDILDNVQY EVNIFEIQDK TLKYRGNISE YMEKNNLNIT
961: KESHWGYSNL NTIDYTRIKL FDEVELNHVK HSNKMIYKEA YFVKGNTESV SFEIDSINKE
1021: YIKKMKKKNY KKEHMNKNNK DNNNNNNNSN KDDHININMN DNHRNYNDIN LGPNSTDDSP
1081: TVSSLGNEYT LDTYTSNNSD KEEIVKPLYK DTHEEFNKSS SMPFVKSSSN MINNPSNFKY
1141: EDNSSSFKGS ISLETYLWYF QQVGFVLLTS VVIFMLISIF TDEIKFVFLT MMSIISKNNK
1201: EHSDTILQKQ VRYLEYFVIL PIISLVTSGI CFSMIIYGNI TSAIKVHNNI LYSILNAPLY
1261: IFYNNNLGNI INRFIIDISA FDYGFLKRIY KAFFIFFRCI LSSLLIIYMI RDCIFIFPFV
1321: IILIYFFVFK RFSRGCKEAQ RLYLSCHTPL CNIYSNALSG KNIINIYKKN TYHLDVYEHY
1381: INNFRISYFI KWLINIWASL YIKIFILLLT TYIIMHPHLY ASGIIKLYKE KNYVRILSTL
1441: GYCISFSARL GVIIKFLLCD YTHIEKEMCC VQRLEEFAKI SNKENASMNK ENELNVITTQ
1501: TYKEKNENIS DKISAIVEYK NVSLSSIINS SQDDESKKKY GIKFENVYVS YKKKIPLVNG
1561: TYKYIDEEPS LKNINMYALK NQKIGIVGKS GAGKSTILLS ILGLINISQG KITVEGRDIR
1621: TYNRKGEDSI IGILAQSSFV FYNWNIRTFI DPYNNFTDDE IVHALKLNGI NLGKNDLYKY
1681: MHKQDMKSNY KKIIQTSKVI NQSNDNTILL TNDCIRYLSL VRLYLNRHKY KIILIDEIPI
1741: FNLNNSVHDE LNSFLIGKAK SFNYIIRNHF PNNTVLIISH HANTLSCCDY IYVLRKGEIT
1801: YRCSYEDVKT QSELSHLLEM DD