3.A.1.208.45
Multidrug resistance pump, MRP1 or ABCC1 of 1515 aas and 17 putative TMSs. The ABCC1 gene is expressed at all larval stages and in at least nine different tissues, particularly in the fifth-instar larvae and Malpighian tubules (Chen et al. 2018). MRP1 (ABCC1) serves as a functional receptor for the insect toxins, Cry1A and Cry2Ab (Chen et al. 2018).
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| Accession Number: | ARE31046 |
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| Protein Name: | ARE31046.1 ABCC1 protein [Helicoverpa armigera] |
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| Length: | 1516 |
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| Molecular Weight: | |
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| Species: | Helicoverpa armigera [29058] |
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| Number of TMSs: | 14 |
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| Substrate |
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1: MSYNSTLDSF CGSQFWNSSL TWYTDSPELT PCFQKTVLVW TPCLYLWAAA FLDTYYILNS
61: KERNIPWNIL NISKLLITCL LIVLKFVDLG VTVHTSSQGE KEVFNADYYS PIIKILTFCL
121: SATLLYYNRK YGMRASGVLF FFWLLLILAG LPQLQSEVKA HYNLSDDENV QYNFVSYMVY
181: YPLIILMFLL NCFADLPPKD TPYKYEKNQC PENASGFPSR LTYSWFDPLA LTGFRRSLTE
241: EDLWALNPQD SSTEVVPKFD KFWEKSLRKR EISNATKATY RKTSASVNFK PESEKKPASI
301: LPALCLAFGG QFLFGSMLKL FNDVLMFLSP QLLKLLIGFV QGKEPIWKGY VYAVALLACA
361: TVQTMLLAHY FTRMYLVGMR IRTALTSAIY RKSLRMSNSA RKESTVGEIV NLMSVDAQRF
421: VELTAYLNMI WSAPLQIALA LYFLWGILGP SVLAGLAVMI ILIPVNGLIA NRVKTLQIRL
481: MKYKDERVKL MNEVLNGIKV LKMYAWEPSF EDQILKIRNK EMNVLKQTAY LNSATSFIWS
541: CAPFLVSLMS FGCFVLVNDT EVLDSKRAFV ALSLFNILRF PLSMLPNVIS NVVQTSVGIK
601: RLNKFMNCDE LDVTSVEHDP KDPNPISIEN GHFTWGEQDS EPFLKNITLH VPRGSLIAVV
661: GAVGSGKSSL LAALLGEMNK LSGRVNTTGT IAYVPQQAWI QNATLQDNIL FGKPLDKQKY
721: NNVIDMCALK PDFEVLPGGD QTEIGEKGIN LSGGQKQRVS LARAVYCDAD NYFLDDPLSA
781: VDSHVGKHIF DKVLGPAGLL KHKTRVWVTH NVSYLMHTDL VVVLRDGEVS EAGSYQQLLE
841: KKGAFADFLL HHLSDAERTS PEELDKIKQD LESKLGTEFQ HKLQRARSLS ESASESEQAA
901: AGDRAGSVKR KTPEATPNEL KEKNKLIEAE KTETGSVKWG VYKHYLMSVG ILSSVITVLM
961: NLILQVFQVG SNYWLTEWAN DDKMLVNGTV DTKRRDMYLG VYGGLGIGQA LASIFADLMP
1021: FLACWRAARI LHELLLDHVL KAPLQFFEVT PLGRIPSRFS KDMDILDTSL PSQISDLMWC
1081: TFEVLGTLFV ISFSTPIFMA VILPIGFIYY VIQRFYVATS RQLKRLESVS RSPIYSHFGE
1141: SITGSSTIRA YGVSERFIEE SERGVDHNQS CYYPSCIANR WLAIRLEMIG NLIIFFSAMF
1201: AVLNRDTISA GLVGLSVSYA LQITQTLNWL VRMTSEVETN IVAVERIKEY AETEQEAPWA
1261: IGAGPPATWP ETGALQLERL TLAYRAGAEP ALRDVTCAVA PRDKLGIVGR TGAGKSTLTL
1321: GLFRIVEAVG GRILIDGLDI ATMGLHQLRS RITIIPQDPV LFSGTLRMNL DPFETFSDED
1381: IWRALEYAHL KPFVQGLPAG LRHEVAEGGE NLSVGQRQLV CLARALLRKT PLLVLDEATA
1441: AVDLETDELI QKTIRSEFAS CTVLTIAHRL NTIMDSTKVM VLDKGQLVEY APPDQLLQDK
1501: NSVFYSMAKD AGLVN