3.A.1.208.48
Multidrug resistance protein, MRP4 or ABCC4, of 1349 aas and 12 TMSs in an M-C-M-C domain order. The non-steroidal anti-inflammatory drug (NSAID) diclofenac, known to cause hyperuricemia and concomitant visceral gout in Gyps vultures may be a result of interference with renal uric acid excretion. Three species of Gyps vultures are on the verge of extinction due to nephrotoxic veterinary diclofenac having entered the food chain, and because the toxicity of different avian species to the NSAIDs like diclofenac varies. MRP4, an organic anion transporter in birds, plays a unique role in unidirectional efflux of urate into the proximal renal tubular lumen for excretion and maintenance of homeostasis. Barik et al. 2019 characterized the MRP4 channel at the molecular level to predict its structural based ligand binding properties in Gallus domesticus (Indian domestic chicken) and Gyps himalayensis (the Himalayan griffon vulture)including point and insertional mutational variants.
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| Accession Number: | AON76441 |
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| Protein Name: | AON76441.1 multidrug resistance protein 4 [Gyps himalayensis] |
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| Length: | 1350 |
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| Molecular Weight: | |
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| Species: | Gyps himalayensis [36248] |
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| Number of TMSs: | 11 |
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| Substrate |
organic anion, 7,9-dihydro-1H-purine-2,6,8(3H)-trione, drug |
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1: MEAVPREEKP NPLRDANLCS RLFFWWLNPL FIIGHKRKLE EDDMYKVLPE DSSKKLGEDL
61: QWYWDKEVQK AKKRGKTPHL TKAIILCYWK SYLVLGIFTM IEETLKIVQP IFLGKIITYF
121: ENYDASDEVA LNVAYCYAAA LSVCTLILAI MHHLYFYHVQ RAGMKLRVAM CHMIYRKALR
181: LSNVAMAKTT TGQIVNLLSN DVNKFDQVTI FLHFLWAGPI QAVAVTVLLW MEIGPSCLAG
241: MAVLIILLPI QTCIGRLFSS LRSKTAALTD VRIRTMNEVI SGMKIIKMYA WEKSFAELVS
301: GLRRKEIAMV LKSSYLRGLN LASFFVASKI TVFMTFMAYV LLGNVISASR VFVAVSLYGA
361: VRLTVTLFFP SAVERVSEAV VSIRRIKNFL ILDEVSHFKP QLHDNNENVI LHVQDLTCYW
421: DKSLESPALQ QLSFTVRQGE LLAVIGPVGA GKSSLLSAVL GELPKEKGLI NVSGRIAYVS
481: QQPWVFSGTV RSNILFDKEY EREKYEKVLK VCALKKDLDL LANGDLTVIG DRGATLSGGQ
541: KARVNLARAV YQDADIYLLD DPLSAVDAEV GRHLFEKCIC QALHQKICVL VTHQLQYLRA
601: ATQILILKDG KMVGKGTYSE FLRSGIDFAS LLKKEEEVEQ PSVPGTPNLK SSRSRTFSES
661: SVWSQDSSIH SVKDGAVEQP PTENALAAVP EESRSEGKIS FKVYRKYFTA GANYFVIFIL
721: VLFNILAQVA YVLQDWWLSY WANHQGKLNV TTNGNNGANE TEHLDLAFYL GIYAGLTVAT
781: ILFGIIRSLL VFQVLVNSGQ TLHNKMFKSI LKAPVLFFDR NPIGRILNRF SKDIGHLDDL
841: LPLTFLDFVQ TLLQIFGVVA VAVAVIPWIL IPLIPLFILF IFLRRYFLDT SRDIKRLEST
901: TRSPVFSHLS SSLQGLWTIR ALKAEDRFQK LFDAHQDLHS EAWFLFLTTS RWFAVRLDAI
961: CAIFVIVVAF GSLLLAKTLN AGQVGLALSY AITLMGTFQW GVRQSAEVEN LMISVERVME
1021: YTDLEKEAPW ETNKHPPPEW PSHGMIAFEN VNFTYSLDGP LVLRHLSVVI KPEEKQSLLH
1081: TSESQAVGNC PLVSVGIVGR TGAGKSSLIA ALFRLAEPEG RIWIDKYLTS ELGLHDLRKK
1141: ISIIPQEPVL FTGTMRKNLD PFNEYTDEEL WNALEEVQLK EAVEDLPNKM ETQLAESGSN
1201: FSVGQRQLVC LARAVLKKNR ILIIDEATAN VDPRTDEFIQ KTIREKFAHC TVLTIAHRLN
1261: TIIDSDRIMV LDAGRLKEYG EPYILLQEKD GLFYKMVQQV GKTEAASLME TAKRVYFRKN
1321: YPEVVQNGQL ATDSSLDPSS GLCITETAL