3.A.1.208.49
Multidrug resistance-associated protein, CG4562, MRP5 or DmeI of 1362 aas and 12 TMSs with an order of domains MCMC, where both M domains probably have 6 TMSs. It has been shown to be a heme exporter, but probably has multiple substrates as is true of human MRP5 (Wang et al. 2022). CG4562 is mainly expressed in the gastric caeca and the anterior part of the midgut, suggesting this is the major site of heme absorption. It thus appears that CG4562 is the functional counterpart of mammalian MRP5 (Wang et al. 2022).
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| Accession Number: | Q9VDT3 |
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| Protein Name: | Uncharacterized protein, isoform A |
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| Length: | 1362 |
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| Molecular Weight: | 152792.00 |
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| Species: | Drosophila melanogaster (Fruit fly) [7227] |
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| Number of TMSs: | 12 |
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| Substrate |
ferroheme b |
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1: MQSMKADELP ENPREKSNIF SSLMFCFAMP TFFKGRKKTL DENDLYRALQ EHRSDHLGSK
61: LSAAWEKEVE KKRKKKKTPS LLKASMNVFG WRLAGLGLVL FILEIGFRVT QPLFLGGLVA
121: YYADASNQEG DNQTKAYLYA LGVILTSACN VLFMHPYMLG MFHIGMKARI AMTSMIYRKA
181: LRLSRTALGD TTIGQVVNLI SNDVGRLDVS VIHMNYLWLG PVEIGIITYL MYREIGISAF
241: FGVAVMLLFI PLQAYLGKKT SVLRLKTALR TDERVRMMNE IISGIQVIKM YAWEIPFSKM
301: INYVRTKEMN AIRNVNYIRG TLQSFIMFVT RISVFVSLVG FVLLGKLLTA EKAFVITAYY
361: NILRNTMTVY FPMGISQFAE LLVSIRRIQT FMLHEETKVR DKSEDLDEQK LGKAGLIAEP
421: TVAQTTGVLK PSSRRTSEAE HSIVISKLKA KWDQKNTDNT LDNISLKFKP RQLVAVIGPV
481: GSGKSSLIQA VLGELNPDSG SVKVNGTLSY ASQEPWLFTG TVRQNILFGL PMDKHRYRTV
541: VKRCALERDF ELLPYADKTI VGERGASLSG GQKARISLAR AVYRKADIYL LDDPLSAVDT
601: HVGRHLFDQC MRGFLREEIV LLVTHQLQFL EQADVIVIMD KGKISAMGTY ESMAKSGLDF
661: AQMLTDPSKK DEGAGDAPDK KSLSRQNSKL RDRHGSISSM ESAAESLAAE SPMQTQEGRV
721: EGRIGMKLYK KYFGANGYGL FIVFAFFCIG AQVLASGGDI FLSYWVNKNG EAERDTFMAR
781: LRRAFPETRI NADTDPVDIY YFTGINVSVI IFSLVRSMLF FYLAMRSSTT LHNTMFQGVT
841: RAAMHFFNTN PSGRILNRFS KDLGQVDEIL PSVMMDVMQI FLAIVGIVVV LCIINVWYIL
901: ATVFLVIVFY LLRVFYLSTS RDVKRLEAVT RSPIYSHLSA SLNGLATIRA FGAQKELIAE
961: FDNYQDMHSS GYYMFLATSR AFGYWLDCVC VVYIAVITLS FFLFSPENGG DVGLAITQAM
1021: GMTGMVQWGM RQSAELENTM TAVERVVEYE DLEPEGDFES KPNKKPPKDW PEDGKIVFDD
1081: LSLKYFPDKA ADYVLRSLNI AIEGCEKVGI VGRTGAGKSS LINALFRLSY NEGAILIDRR
1141: DTNDLGLHDL RSKISIIPQE PVLFSGTMRY NLDPFDEYSD AKLWESLEEV KLKQVVADLP
1201: SGLQSKISEG GTNFSVGQRQ LVCLARAILR ENRILVMDEA TANVDPQTDA LIQTTIRNKF
1261: KDCTVLTIAH RLHTVMDSDK VLVMDAGKAV EFGSPFELLT TSEKKVFHSM VKQTGDSTFD
1321: ALLKVAQKVG LRFKIQCNLS TCLSSLSSFQ AHDDNLRLKK DS