3.A.1.208.52
Glutathione S-conjugate pump 8, ABCC6; MDR8 with 1466 aas and probably 17 TMSs in a 5 + 6 + 6 TMS arrangement. Haplotypes of CaABCC6 in chickpea are associated with salinity tolerance and leaf necrosis via oxidative stress (Khassanova et al. 2024).
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| Accession Number: | Q8VZZ4 |
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| Protein Name: | ABC transporter C family member 6 |
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| Length: | 1466 |
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| Molecular Weight: | 164367.00 |
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| Species: | Arabidopsis thaliana (Mouse-ear cress) [3702] |
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| Number of TMSs: | 15 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MENPIDSLLL QPIYLSVLSF FLNLVLLLIL FGSWLFKKRV ACEDTDAIMN EEFKHISFSY
61: NKLVLICCVS LSVFYSVLSL LSCLHWHTNG WPFLDLLLAA LTWGSISVYL FGRYTNSCEQ
121: KVLFLLRVWW VFFFVVSCYH LVVDFVLYKK QEMVSVHFVI SDLVGVCAGL FLCCSCLWKK
181: GEGERIDLLK EPLLSSAESS DNEEVTAPFS KAGILSRMSF SWMSPLITLG NEKIIDIKDV
241: PQLDRSDTTE SLFWIFRSKL EWDDGERRIT TFKLIKALFL SVWRDIVLSA LLAFVYTVSC
301: YVAPYLMDNF VQYLNGNRQY KNQGYVLVTT FFVAKLVECQ TQRQWFFRGQ KAGLGMRSVL
361: VSMIYEKGLT LPCHSKQGHT SGEIINLMAV DADRISAFSW FMHDPWILVL QVSLALWILY
421: KSLGLGSIAA FPATILVMLA NYPFAKLEEK FQSSLMKSKD NRMKKTSEVL LNMKILKLQG
481: WEMKFLSKIL ELRHIEAGWL KKFVYNSSAI NSVLWAAPSF ISATAFGACL LLKIPLESGK
541: ILAALATFRI LQGPIYKLPE TISMIVQTKV SLNRIASFLC LDDLQQDVVG RLPSGSSEMA
601: VEISNGTFSW DDSSPIPTLR DMNFKVSQGM NVAICGTVGS GKSSLLSSIL GEVPKISGNL
661: KVCGRKAYIA QSPWIQSGKV EENILFGKPM EREWYDRVLE ACSLNKDLEI LPFHDQTVIG
721: ERGINLSGGQ KQRIQIARAL YQDADIYLFD DPFSAVDAHT GSHLFKEVLL GLLRHKTVIY
781: VTHQVEFLPE ADLILVMKDG KITQAGKYHE ILDSGTDFME LVGAHTEALA TIDSCETGYA
841: SEKSTTDKEN EVLHHKEKQE NGSDNKPSGQ LVQEEEREKG KVGFTVYKKY MALAYGGAVI
901: PLILVVQVLF QLLSIGSNYW MTWVTPVSKD VEPPVSGFTL ILVYVLLAVA SSFCILIRAL
961: LVAMTGFKMA TELFTQMHLR IFRASMSFFD ATPMGRILNR ASTDQSVADL RLPGQFAYVA
1021: IAAINILGII GVIVQVAWQV LIVFIPVVAA CAWYRQYYIS AARELARLAG ISRSPVVHHF
1081: SETLSGITTI RSFDQEPRFR GDIMRLSDCY SRLKFHSTGA MEWLCFRLEL LSTFAFASSL
1141: VILVSAPEGV INPSLAGLAI TYALNLNTLQ ATLIWTLCDL ENKMISVERM LQYTNIPSEP
1201: PLVIETTRPE KSWPSRGEIT ICNLQVRYGP HLPMVLHGLT CTFPGGLKTG IVGRTGCGKS
1261: TLIQTLFRIV EPAAGEIRID GINILSIGLH DLRSRLSIIP QDPTMFEGTI RSNLDPLEEY
1321: TDDQIWEALD NCQLGDEVRK KELKLDSPVS ENGQNWSVGQ RQLVCLGRVL LKRSKLLVLD
1381: EATASIDTAT DNLIQETLRH HFADCTVITI AHRISSVIDS DMVLLLDQGL IKEHDSPARL
1441: LEDRSSLFSK LVAEYTTSSE SKSKRS