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3.A.1.210.8
Mitochondrial ABC transporter, ATM3, involved in iron homeostasis (Chen et al. 2007) and heavy metal resistance (Kim et al. 2006). There are three isoforms: ATM1, ATM2 and ATM3 (Chen et al., 2007). ATM3 can replace the yeast iron/sulfur cluster exporter better than ATM1 or ATM2. Atm3 is most similar to the human and yeast homologues, TC# 3.A.1.210.4 and 3.A.1.210.1, 51% and 47% identical, respectively.  It may function in cytosolic iron-sulfur cluster biogenesis (Bernard et al. 2009) as well as molybdenum cofactor biosynthesis (Teschner et al. 2010).  It performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating export of Fe/S cluster precursors. Not required for mitochondrial and plastid Fe-S enzymes. Probably involved in the export of cyclic pyranopterin monophosphate (cPMP) from mitochondria into the cytosol. Mediates glutathione-dependent resistance to heavy metals such as cadmium and lead, as well as their transport from roots to leaves. Regulates nonprotein thiols (NPSH) and the cellular level of glutathione (GSH); but see also, 3.A.210.15.  This protein, also called ABCB25, is of 728 aas with 6 TMSs and a domain order of MC.  It transports glutathione poly sulfides (Lefèvre and Boutry 2018).

Accession Number:Q9LVM1
Protein Name:ABC transporter-like protein aka ATM3
Length:728
Molecular Weight:80420.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate metal cation, iron(2+), precursor Z hydrate

Cross database links:

RefSeq: NP_200635.1   
Entrez Gene ID: 835939   
Pfam: PF00664    PF00005   
KEGG: ath:AT5G58270   

Gene Ontology

GO:0009941 C:chloroplast envelope
GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane m...
GO:0006879 P:cellular iron ion homeostasis
GO:0009658 P:chloroplast organization
GO:0006826 P:iron ion transport
GO:0009555 P:pollen development
GO:0050790 P:regulation of catalytic activity
GO:0010380 P:regulation of chlorophyll biosynthetic process
GO:0046686 P:response to cadmium ion
GO:0010288 P:response to lead ion
GO:0048364 P:root development
GO:0055085 P:transmembrane transport

References (11)

[1] “A mutation of the mitochondrial ABC transporter Sta1 leads to dwarfism and chlorosis in the Arabidopsis mutant starik.”  Kushnir S.et.al.   11158531
[2] “Functional characterization of AtATM1, AtATM2, and AtATM3, a subfamily of Arabidopsis half-molecule ATP-binding cassette transporters implicated in iron homeostasis.”  Chen S.et.al.   17517886
[3] “Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence features of the regions of 3,076,755 bp covered by sixty P1 and TAC clones.”  Sato S.et.al.   10718197
[4] “Empirical analysis of transcriptional activity in the Arabidopsis genome.”  Yamada K.et.al.   14593172
[5] “The Arabidopsis thaliana ABC protein superfamily, a complete inventory.”  Sanchez-Fernandez R.et.al.   11346655
[6] “Multifunctionality of plant ABC transporters -- more than just detoxifiers.”  Martinoia E.et.al.   11855639
[7] “The hydrophobic proteome of mitochondrial membranes from Arabidopsis cell suspensions.”  Brugiere S.et.al.   15276431
[8] “Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins.”  Heazlewood J.L.et.al.   14671022
[9] “Mapping the Arabidopsis organelle proteome.”  Dunkley T.P.J.et.al.   16618929
[10] “AtATM3 is involved in heavy metal resistance in Arabidopsis.”  Kim D.-Y.et.al.   16461380
[11] “Plant ABC proteins - a unified nomenclature and updated inventory.”  Verrier P.J.et.al.   18299247

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MSRGSRFVRA PGLLLCRVNL QPQPKIPSFS YSLRSDYRLH NGFSNYIRRN SIRTSPVINA 
61:	FLSDNSPSPS PSPSPIRFVQ RSSMLNGRLF STSTPNPDQT TTKTKEIKTT SSDSDSAMAD 
121:	MKILRTLAGY LWMRDNPEFR FRVIAALGFL VGAKVLNVQV PFLFKLAVDW LASATGTGAS 
181:	LTTFAATNPT LLTVFATPAA VLIGYGIART GSSAFNELRT AVFSKVALRT IRSVSRKVFS 
241:	HLHDLDLRYH LSRETGGLNR IIDRGSRAIN FILSAMVFNV VPTILEISMV SGILAYKFGA 
301:	AFAWITSLSV GSYIVFTLAV TQWRTKFRKA MNKADNDAST RAIDSLINYE TVKYFNNEGY 
361:	EAEKYDQFLK KYEDAALQTQ RSLAFLNFGQ SIIFSTALST AMVLCSQGIM NGQMTVGDLV 
421:	MVNGLLFQLS LPLNFLGSVY RETIQSLVDM KSMFQLLEEK SDITNTSDAK PLVLKGGNIE 
481:	FENVHFSYLP ERKILDGISF VVPAGKSVAI VGTSGSGKST ILRMLFRFFD TDSGNIRIDG 
541:	QDIKEVRLDS LRSSIGVVPQ DTVLFNDTIF HNIHYGRLSA TEEEVYEAAR RAAIHETISN 
601:	FPDKYSTIVG ERGLKLSGGE KQRVALARTF LKSPAILLCD EATSALDSTT EAEILNALKA 
661:	LASNRTSIFI AHRLTTAMQC DEIVVLENGK VVEQGPHDEL LGKSGRYAQL WTQQNSSVDM 
721:	LDAAIKLE