3.A.1.211.17
ATP-binding cassette sub-family A member 10, ABCA10 of 1543 aas. May play a role in macrophage lipid homeostasis. Highly expressed in skeletal muscle, heart, brain and gastrointestinal tract. Down-regulated by cholesterol loading of macrophages (Sakamoto et al. 2019).
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| Accession Number: | Q8WWZ4 |
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| Protein Name: | ATP-binding cassette sub-family A member 10 |
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| Length: | 1543 |
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| Molecular Weight: | 175790.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 14 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
lipid |
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1: MNKMALASFM KGRTVIGTPD EETMDIELPK KYHEMVGVIF SDTFSYRLKF NWGYRIPVIK
61: EHSEYTEHCW AMHGEIFCYL AKYWLKGFVA FQAAINAAII EVTTNHSVME ELTSVIGINM
121: KIPPFISKGE IMNEWFHFTC LVSFSSFIYF ASLNVARERG KFKKLMTVMG LRESAFWLSW
181: GLTYICFIFI MSIFMALVIT SIPIVFHTGF MVIFTLYSLY GLSLIALAFL MSVLIRKPML
241: AGLAGFLFTV FWGCLGFTVL YRQLPLSLGW VLSLLSPFAF TAGMAQITHL DNYLSGVIFP
301: DPSGDSYKMI ATFFILAFDT LFYLIFTLYF ERVLPDKDGH GDSPLFFLKS SFWSKHQNTH
361: HEIFENEINP EHSSDDSFEP VSPEFHGKEA IRIRNVIKEY NGKTGKVEAL QGIFFDIYEG
421: QITAILGHNG AGKSTLLNIL SGLSVSTEGS ATIYNTQLSE ITDMEEIRKN IGFCPQFNFQ
481: FDFLTVRENL RVFAKIKGIQ PKEVEQEVKR IIMELDMQSI QDIIAKKLSG GQKRKLTLGI
541: AILGDPQVLL LDEPTAGLDP FSRHRVWSLL KEHKVDRLIL FSTQFMDEAD ILADRKVFLS
601: NGKLKCAGSS LFLKRKWGIG YHLSLHRNEM CDTEKITSLI KQHIPDAKLT TESEEKLVYS
661: LPLEKTNKFP DLYSDLDKCS DQGIRNYAVS VTSLNEVFLN LEGKSAIDEP DFDIGKQEKI
721: HVTRNTGDES EMEQVLCSLP ETRKAVSSAA LWRRQIYAVA TLRFLKLRRE RRALLCLLLV
781: LGIAFIPIIL EKIMYKVTRE THCWEFSPSM YFLSLEQIPK TPLTSLLIVN NTGSNIEDLV
841: HSLKCQDIVL EIDDFRNRNG SDDPSYNGAI IVSGDQKDYR FSVACNTKKL NCFPVLMGIV
901: SNALMGIFNF TELIQMESTS FSRDDIVLDL GFIDGSIFLL LITNCVSPFI GMSSISDYKK
961: NVQSQLWISG LWPSAYWCGQ ALVDIPLYFL ILFSIHLIYY FIFLGFQLSW ELMFVLVVCI
1021: IGCAVSLIFL TYVLSFIFRK WRKNNGFWSF GFFIILICVS TIMVSTQYEK LNLILCMIFI
1081: PSFTLLGYVM LLIQLDFMRN LDSLDNRINE VNKTILLTTL IPYLQSVIFL FVIRCLEMKY
1141: GNEIMNKDPV FRISPRSRET HPNPEEPEEE DEDVQAERVQ AANALTAPNL EEEPVITASC
1201: LHKEYYETKK SCFSTRKKKI AIRNVSFCVK KGEVLGLLGH NGAGKSTSIK MITGCTKPTA
1261: GVVVLQGSRA SVRQQHDNSL KFLGYCPQEN SLWPKLTMKE HLELYAAVKG LGKEDAALSI
1321: SRLVEALKLQ EQLKAPVKTL SEGIKRKLCF VLSILGNPSV VLLDEPFTGM DPEGQQQMWQ
1381: ILQATVKNKE RGTLLTTHYM SEAEAVCDRM AMMVSGTLRC IGSIQHLKNK FGRDYLLEIK
1441: MKEPTQVEAL HTEILKLFPQ AAWQERYSSL MAYKLPVEDV HPLSRAFFKL EAMKQTFNLE
1501: EYSLSQATLE QVFLELCKEQ ELGNVDDKID TTVEWKLLPQ EDP