3.A.1.211.26
ABCA17 or ABCAH or 1733 aas and 12 TMSs in a MCMC domain arrangement. ABCA17 mRNA is expressed exclusively in the testis, ABCA17 mRNA is expressed in germ cells, mainly spermatocytes, in the seminiferous tubule. It is localized in the endoplasmic reticulum, and intracellular esterified lipids, including cholesteryl esters, fatty acid esters and triacylglycerols, were decreased in cells stably expressing ABCA17. Thus, ABCA17 may play a role in regulating the lipid composition in sperm (Ban et al. 2005).
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| Accession Number: | E9PX95 |
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| Protein Name: | ATP-binding cassette sub-family A member 17 |
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| Length: | 1733 |
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| Molecular Weight: | 196020.00 |
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| Species: | Mus musculus (Mouse) [10090] |
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| Number of TMSs: | 13 |
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| Location1 / Topology2 / Orientation3: |
Endoplasmic reticulum membrane1 / Multi-pass membrane protein2 |
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| Substrate |
cholesteryl ester, triglyceride, fatty acid ester |
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1: MEVLKKLKLL LWKNFILKRR KTLITLLEML MPLLFCAIVL YLRLNSMPRK KSSTNYPAVD
61: VSLLPVYFYN YPLKSKFQLA YIPSKSETLK AVTEVVEQTF AVDFEVLGFP SVPLFEDYII
121: KDPKSFYILV GIIFHHDFNS SNEPLPLVVK YDLRFSYVQR NFVSPPRHLF FQEEIEGWCT
181: AFLYPPNLSQ APREFSYADG GNPGYNKEGF LAIQHAVDKA IMRHHAPKAA LNMFKDLHVL
241: VQRFPFGPHI QDPFLVILQN EFPLLLMLSF ICVELIITNS VLSEKERKQK EYMSMMGVES
301: WLHWVAWFIT FFISVSITVS VMTVLFCTKI NRVAVFRNSN PTLIFIFLMC FAIATIFFAF
361: MMSTFFQRAH VGTVIGGTVF FFTYLPYMYI TFSYHQRTYT QKILSCLFSN VAMATGVRFI
421: SLFEAEGTGI QWRNIGSVWG DFSFAQVLGM LLLDSFLYCL IAFLVESLFP RKFGIPKSWY
481: IFAKKPVPEI PPLLNIGDPE KPSKGNFMQD EPTNQMNTIE IQHLYKVFYS GRSKRTAIRD
541: LSMNLYKGQV TVLLGHNGAG KTTVCSVLTG LITPSKGHAY IHGCEISKDM VQIRKSLGWC
601: PQHDILFDNF TVTDHLYFYG QLKGLSPQDC HEQTQEMLHL LGLKDKWNSR SKFLSGGMKR
661: KLSIGIALIA GSKVLILDEP TSGLDSPSRR AIWDLLQQQK GDRTVLLTTH FMDEADLLGD
721: RIAILAKGEL QCCGSPSFLK QKYGAGYYMT IIKTPLCDTS KLSEVIYHHI PNAVLESNIG
781: EEMIVTLPKK TIHRFEALFN DLELRQTELG ISTFATSVTT MEEVFIRVCK LADPSTNVLT
841: EKRHSLHPLP RHHRVPVDRI KCLHSGTFPV STEQPMRLNT GFCLLCQQFY AMLLKKITYS
901: RRNWMLVLSV QVLLPLAIIM LSLTFFNFKL RKLDNVPLEL TLQTYGQTIV PFFIAENSHL
961: DPQLSDDFVK MLVAAGQVPL RIQGSVEDFL LKKAKEAPEG FDKLYVVAAS FEDVNNHTTV
1021: KALFNNQAYH SPSLALTLVD NLLFKLLSGA NASITTTNYP QPQTAIEVSE SILYQGPKGH
1081: YLVVNFLFGI AFLSSSFSIL TVGEKSVKSK SLQFVSGVST AVFWLSALLW DLISFLVPTL
1141: LLVLVFLWYK EEAFAHHESI PAVVLIMMLY GWAVIPLVYT VSFSFNTPGS ACVKLVVMLT
1201: FLSISPVVLV TVTSEKDLGY TELSDSLDHI FLILPGHCLG MALSNLYYNF ELKKFCSAKN
1261: LSDIDCNDVL EGYVVQENIY AWESLGIGKY LTALAVLGPV YITMLFLTEA NAFYVLKSRL
1321: SGFFPSFWKE KSGMIFDVAE PEDEDVLEEA ETIKRYLETL VKKNPLVVKE VSKVYKDKVP
1381: LLAVNKVSFV VKEEECFGLL GLNGAGKTSI FNMLTSEQPI TSGDAFVKGF NIKSDIAKVR
1441: QWIGYCPEFD ALLNFMTGRE MLVMYARIRG IPECHIKACV DLILENLLMC VCADKLVKTY
1501: SGGNKRMLST GIALVGEPAV ILLDEPSTGM DPVARRLLWD TVERVRESGK TIVITSHSME
1561: ECEALCTRLA IMVQGQFKCL GSPQHLKSKF GISYSLQAKV RRKWQQQMLE EFKAFVDLTF
1621: PGSNLEDEHQ NMLQYYLPGP NLSWAKVFSI MEQAKKDYML EDYSISQLSL EDIFLNFTRP
1681: ESSTKEQIQQ EQAVLASPSP PSNSRPISSP PSRLSSPTPK PLPSPPPSEP ILL