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| Accession Number: | O94911 |
| Protein Name: | ATP-binding cassette sub-family A member 8 |
| Length: | 1581 |
| Molecular Weight: | 179245.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 15 |
| Location1 / Topology2 / Orientation3: | Cell membrane1 / Multi-pass membrane protein2 |
| Substrate | p-aminohippuric acid, taurocholic acid, leukotriene C4, ochratoxin A |
Cross database links:
| RefSeq: | NP_009099.1 |
|---|---|
| Entrez Gene ID: | 10351 |
| Pfam: | PF00005 |
| OMIM: |
612505 gene |
| KEGG: | hsa:10351 |
Gene Ontology
GO:0016021
C:integral to membrane
GO:0005886
C:plasma membrane
GO:0005524
F:ATP binding
GO:0042626
F:ATPase activity, coupled to transmembrane m...
GO:0006810
P:transport
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References (5)[1] “Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.” Nagase T.et.al. 10048485 [2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [3] “Functional analysis of ABCA8, a new drug transporter.” Tsuruoka S.et.al. 12379217 [4] “Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.” Chen R.et.al. 19159218 [5] “Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding human ATP-binding cassette transporters: ABCA4, ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8.” Iida A.et.al. 12111378
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MRKRKISVCQ QTWALLCKNF LKKWRMKRES LMEWLNSLLL LLCLYIYPHS HQVNDFSSLL 61: TMDLGRVDTF NESRFSVVYT PVTNTTQQIM NKVASTPFLA GKEVLGLPDE ESIKEFTANY 121: PEEIVRVTFT NTYSYHLKFL LGHGMPAKKE HKDHTAHCYE TNEDVYCEVS VFWKEGFVAL 181: QAAINAAIIE ITTNHSVMEE LMSVTGKNMK MHSFIGQSGV ITDLYLFSCI ISFSSFIYYA 241: SVNVTRERKR MKALMTMMGL RDSAFWLSWG LLYAGFIFIM ALFLALVIRS TQFIILSGFM 301: VVFSLFLLYG LSLVALAFLM SILVKKSFLT GLVVFLLTVF WGCLGFTSLY RHLPASLEWI 361: LSLLSPFAFM LGMAQLLHLD YDLNSNAFPH PSDGSNLIVA TNFMLAFDTC LYLALAIYFE 421: KILPNEYGHR RPPLFFLKSS FWSQTQKTDH VALEDEMDAD PSFHDSFEQA PPEFQGKEAI 481: RIRNVTKEYK GKPDKIEALK DLVFDIYEGQ ITAILGHSGA GKSTLLNILS GLSVPTKGSV 541: TIYNNKLSEM ADLENLSKLT GVCPQSNVQF DFLTVRENLR LFAKIKGILP QEVDKEIFLL 601: DEPTAGLDPF SRHQVWNLLK ERKTDRVILF STQFMDEADI LADRKVFLSQ GKLKCAGSSL 661: FLKKKWGIGY HLSLQLNEIC VEENITSLVK QHIPDAKLSA KSEGKLIYTL PLERTNKFPE 721: LYKDLDSYPD LGIENYGVSM TTLNEVFLKL EGKSTINESD IAILGEVQAE KADDTERLVE 781: MEQVLSSLNK MRKTIGGVAL WRQQICAIAR VRLLKLKHER KALLALLLIL MAGFCPLLVE 841: YTMVKIYQNS YTWELSPHLY FLAPGQQPHD PLTQLLIINK TGASIDDFIQ SVEHQNIALE 901: VDAFGTRNGT DDPSYNGAIT VCCNEKNYSF SLACNAKRLN CFPVLMDIVS NGLLGMVKPS 961: VHIRTERSTF LENGQDNPIG FLAYIMFWLV LTSSCPPYIA MSSIDDYKNR ARSQLRISGL 1021: SPSAYWFGQA LVDVSLYFLV FVFIYLMSYI SNFEDMLLTI IHIIQIPCAV GYSFSLIFMT 1081: YVISFIFRKG RKNSGIWSFC FYVVTVFSVA GFAFSIFESD IPFIFTFLIP PATMIGCLFL 1141: SSHLLFSSLF SEERMDVQPF LVFLIPFLHF IIFLFTLRCL EWKFGKKSMR KDPFFRISPR 1201: SSDVCQNPEE PEGEDEDVQM ERVRTANALN STNFDEKPVI IASCLRKEYA GKRKGCFSKR 1261: KNKIATRNVS FCVRKGEVLG LLGHNGAGKS TSIKVITGDT KPTAGQVLLK GSGGGDALEF 1321: LGYCPQENAL WPNLTVRQHL EVYAAVKGLR KGDAEVAITR LVDALKLQDQ LKSPVKTLSE 1381: GIKRKLCFVL SILGNPSVVL LDEPSTGMDP EGQQQMWQAI RATFRNTERG ALLTTHYMAE 1441: AEAVCDRVAI MVSGRLRCIG SIQHLKSKFG KDYLLEMKVK NLAQVEPLHA EILRLFPQAA 1501: RQERYSSLMV YKLPVEDVQP LAQAFFKLEK VKQSFDLEEY SLSQSTLEQV FLELSKEQEL 1561: GDFEEDFDPS VKWKLLPQEE P