3.A.1.29.2
This ABC uptake porter of unknown substrate specificity is unusual in that all four subunits of a typical ECF transporter occur in a single polypeptide chain of 1148 aas with the domain order as follows: (1) a hydrophilic domain of ~200 aas, (2) the S (substrate binding) domain, (3) the first ATPase domain, (4) another hydrophilic domain, (5) the second ATPase domiain, (6) the T (transducer) domain. It is not unusual for eukaryotes to fuse domains of an ABC porter together, but this is the first one we have observed in this type of ABC transporter. Based on its similarity with TC# 3.A.1.29.1, it may transport Methionine, but the entry in NCBI indicates possible substrates to be Co2+ or riboflavin (based only on sequence similarity).
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| Accession Number: | KAI7259335.1 |
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| Protein Name: | KAI7259335.1 hypothetical protein KC345_g10332 [Hortaea werneckii] |
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| Length: | 1149 |
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| Molecular Weight: | |
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| Species: | Hortaea werneckii [91943] |
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| Number of TMSs: | 8 |
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| Substrate |
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1: MPLPAVQAVL ENGDELDVTD TIVWELSGSN AVLKQSTTAK TIKGLVKGSA TLKGTYSNKT
61: ISVPVTIEQK VVKLVVEPGT LEMNIKGSKT IKVTGYFSNG KTATFSGAMN WVSSNPDVAS
121: VKGTTVKAIT EGTATLSGSY QGITATVKIS VVPKLMKITV SENKLALAPG ASKSVAVTAL
181: YDTGKSAVVT GSVVWTSSKS SVATVNSFGQ ITATIVAIGI GSPLFVILGR FGSIPSGIPN
241: TNIETTYALL ALFALLYGPV AGLFIGLIGH TLKDAIFYGS PWFSWVISSG LVGLLIGLLV
301: ARISIRDGEF GRKEIIGFNL AQIVANAIAW FVVAPLLDIL IYAEPANKVF TQGLIAGASN
361: IVTVAVIGTL LAIAYAKTRT KQEFADFTFK YRAQQEPTLH NINLKINEGE KILIVGPSGS
421: GKSTLAHCIN GLIPFAYPGE MSGSLTVKGR DTRELGIAGL SEVVGTVLQD PDGQFVGLTV
481: GEDIAFSLEN AAVPVPEMHE RVAAAARAVD IQQLLSASPQ ELSGGQKQKT MLAGVLVSNV
541: DILLFDEPLA SLDPYTGTGA IELIDRVQRE TGNTVIIIEH RLEEVLHRHV DRIIVINEGV
601: IAADMPAAEL LSSPLLAESG IREPLYLTAL KYAGCEITPE MHPEHLDGIS LETGAAKLRS
661: WYEYSEAPLE EEAAPVLLEL RDISFGYDKK AQVLQGLSFS VRRGEMLCIA GRNGAGKSTV
721: SKLICGFYRP SAGSILLNGR DLASDTIKER AEHIGFVMQN PNHMISLTLL FDEVALGLKL
781: RGFAEEEIRE RVHRVLQICG LYEFREWPVS ALSYGQKKRV TIASILVLEP EVLILDEPTA
841: GQDYRHYNEI MEFLRGLGSS GITVIMITHD MHLMLEYAER TIVLAEGTKL ADERPEVILT
901: DRNIDSPVHR LTGAAKLIIF AVCLAVFRIS RVRFQDYAFV LYFILFFFLL NHIAIFVFSP
961: LEGTRIYGTR HDLLHLAGRY TLTSEQLFYQ FNIALKYAVV IPMALLFLLT TDPSEFAASL
1021: NRVGVNYKIA YSVSLALRYI PDIQQDYENI SFSAQARGID ISRKEKLPKR LKNIVSILLP
1081: LILTSIERIE KISTAMELRG FGTGRSRTWY QARPFTRSDY FALCLMVGIA AATTIITFYD
1141: GSRFYSIF