3.A.1.3.25
Glutamine transporter, GlnQP. Takes up glutamine, asparagine and glutamate which compete for each other for binding to the substrate/transmembrane protein constituent of the system (Fulyani et al. 2015). Tandem substrate binding domains differ in substrate specificity and affinity, allowing cells to efficiently accumulate
different amino acids via a single ABC transporter. Analysis revealed the roles of individual residues in determining the substrate
affinity (Fulyani et al. 2013). Protein-protein interactions and conformational states were studied simultaneously using PIFE-FRET (Ploetz et al. 2021).
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| Accession Number: | Q9CES5 |
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| Protein Name: | Glutamine ABC transporter permease and substrate binding protein protein |
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| Length: | 714 |
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| Molecular Weight: | 78377.00 |
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| Species: | Lactococcus lactis subsp. lactis (strain IL1403) [272623] |
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| Number of TMSs: | 6 |
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| Substrate |
asparagine, glutamine, glutamate(2-) |
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1: MKKLFFALAM MLATVTAFLV APSVKAETTV KIASDSSYAP FEFQNGQKKW VGIDVDIMQE
61: VAKINDWKLE MSYPGFDAAL QNLKAGQVDG IIAGMTITDE RKETFDFSNP YYTSALTIAT
121: TKDSKLSDYS DLKGKAVGAK NGTAAQTWLQ ENQKKYGYTI KTYSDGVHMF AALSSGNIAG
181: AMDEVPVISY AMKQGQDLAM NFPSISLPGG YGFAVMKGKN STLVDGFNKA LAEMKSNGDY
241: DKILKKYGIT ATKKATPKKD VYTIASDNSF APFEFQNDDK QFTGIDVDLL NAIAKNQGFK
301: LKWNFIGFQA AVDSVQSGHA DGMMSGMSIT DARKQVFDYG SPYYSSNLTI ATSSTDDSIK
361: SWKDLKGKTL GAKNGTASFD YLNAHAKEYG YTVKTFTDAT TMYSSLNNGS INALMDDEPV
421: IKYAIKQGQK FATPIKPIPD GQYGFAVKKG SNPELIEMFN NGLANLRANG EYDKIIDKYL
481: ESDAKTIQSS AKENTFFGIL QNNWEQIGRG LLVTLELAIL SFILAMIVGI IFGLFSVAPS
541: KILRTIARIY VDLNRSIPLL VLTIFIFYGI PNLLQIITGH QSPLNEFTAG VIALTLNSSA
601: YIAEIVRSGV QAVPSGQMEA SRSLGVTYLT SMRKVILPQA IKITIPSLIN QFIITLKDTT
661: LVSVIGLVEL LQTGQIIVAR NFQAFRVYGL IGLVYMIVLL FLMWIGRRVE KRMK