3.A.1.3.27
Basic amino acid uptake porter, ArtIQ2N2. Transports Arginine, lysine and histidine. Several 3-d structures have been solved (4YMS, 4YMT, 4YMU, etc., Yu et al. 2015). These revealed one binding site for substrate per ArtQ monomer. Heuveling et al. 2018 then showed that in the close homologue, ArtMP of Geobacillus stearothermophilus, that just one of these two sites needed to bind substrate to get transport.
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| Accession Number: | Q8RCC4 |
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| Protein Name: | ABC-type amino acid transport system, periplasmic component |
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| Length: | 260 |
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| Molecular Weight: | 28849.00 |
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| Species: | Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) [273068] |
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| Number of TMSs: | 1 |
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| Substrate |
lysine, arginine, histidine |
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1: MNKKSLFLAF AVVFALAFML SGCGSKFNTV DQIKQKGVIV MGTSADFPPF EFHKVEGGKD
61: EIVGFDIDIA NAIAKKLGVK LEIKDMDFKG LIPALQAGRV DMVIAGMTPT AERKKSVDFS
121: DLYYDSRQVV VVKNDSPISK FDDLKVKTIA VQIGTTSEEA AKKIPNVKLK QLNRVSDEFM
181: DLQNGRCDAI VVEDTVAKAY LKEYKDMKIL YMDEINNVEN GSAVAVAKGN KSLLDVVNEV
241: IKELKQSGEY DKLVDKWFKQ