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3.A.1.3.29
Histidine/Arginine/Lysine (basic amino acid) uptake porter, HisJ/ArgT/HisP/HisM/HisQ [R, R, C, M, M, respectively] (Gilson et al. 1982). HisJ binds L-His (preferred), but 1-methyl-L-His and 3-methyl-L-His also bind, while the dipeptide carnosine binds weakly; D-histidine and the histidine degradation products, histamine, urocanic acid and imidazole do not bind. L-Arg, homo-L-Arg, and post-translationally modified methylated Arg-analogs also bind with the exception of symmetric dimethylated-L-Arg. L-Lys and L-Orn show weaker interactions with HisJ and methylated and acetylated Lys variants show poor binding.The carboxylate groups of these amino acids and their variants are essential (Paul et al. 2016).

Accession Number:P0AEU0
Protein Name:Histidine-binding periplasmic protein
Length:260
Molecular Weight:28483.00
Species:Escherichia coli (strain K12) [83333]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Periplasm1
Substrate lysine, arginine, histidine

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Structure:
1HSL     

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FASTA formatted sequence
1:	MKKLVLSLSL VLAFSSATAA FAAIPQNIRI GTDPTYAPFE SKNSQGELVG FDIDLAKELC 
61:	KRINTQCTFV ENPLDALIPS LKAKKIDAIM SSLSITEKRQ QEIAFTDKLY AADSRLVVAK 
121:	NSDIQPTVES LKGKRVGVLQ GTTQETFGNE HWAPKGIEIV SYQGQDNIYS DLTAGRIDAA 
181:	FQDEVAASEG FLKQPVGKDY KFGGPSVKDE KLFGVGTGMG LRKEDNELRE ALNKAFAEMR 
241:	ADGTYEKLAK KYFDFDVYGG