3.A.1.31.4
RNase L inhibitor of 599 aas, ABCE1; lacks a TMS, and is not a transporter. It antagonizes the binding of 2-5A (5'-phosphorylated
2',5'-linked oligoadenylates) by RNase L through direct interaction
with RNase L and therefore inhibits its endoribonuclease activity. It may also
play a central role in the regulation of mRNA turnover (Le Roy et al. 2001). It antagonizes the
anti-viral effect of the interferon-regulated 2-5A/RNase L pathway, and may
act as a chaperone for post-translational events during HIV-1 capsid
assembly (Martinand et al. 1999).
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| Accession Number: | P61221 |
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| Protein Name: | ATP-binding cassette sub-family E member 1 |
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| Length: | 599 |
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| Molecular Weight: | 67314.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Location1 / Topology2 / Orientation3: |
Cytoplasm1 |
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| Substrate |
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1: MADKLTRIAI VNHDKCKPKK CRQECKKSCP VVRMGKLCIE VTPQSKIAWI SETLCIGCGI
61: CIKKCPFGAL SIVNLPSNLE KETTHRYCAN AFKLHRLPIP RPGEVLGLVG TNGIGKSTAL
121: KILAGKQKPN LGKYDDPPDW QEILTYFRGS ELQNYFTKIL EDDLKAIIKP QYVDQIPKAA
181: KGTVGSILDR KDETKTQAIV CQQLDLTHLK ERNVEDLSGG ELQRFACAVV CIQKADIFMF
241: DEPSSYLDVK QRLKAAITIR SLINPDRYII VVEHDLSVLD YLSDFICCLY GVPSAYGVVT
301: MPFSVREGIN IFLDGYVPTE NLRFRDASLV FKVAETANEE EVKKMCMYKY PGMKKKMGEF
361: ELAIVAGEFT DSEIMVMLGE NGTGKTTFIR MLAGRLKPDE GGEVPVLNVS YKPQKISPKS
421: TGSVRQLLHE KIRDAYTHPQ FVTDVMKPLQ IENIIDQEVQ TLSGGELQRV ALALCLGKPA
481: DVYLIDEPSA YLDSEQRLMA ARVVKRFILH AKKTAFVVEH DFIMATYLAD RVIVFDGVPS
541: KNTVANSPQT LLAGMNKFLS QLEITFRRDP NNYRPRINKL NSIKDVEQKK SGNYFFLDD