3.A.10.1.17
H+-transporting pyrophosphatase of 816 aas (Drozdowicz et al. 2003). It is inhibited by 5-10 μM aminomethylenediphosphonate (AMDP) which also inhibits trypomastigotes and parasite growth (Drozdowicz et al. 2003).
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| Accession Number: | B6KH90 |
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| Protein Name: | H-translocating inorganic pyrophosphatase TV P,putative |
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| Length: | 816 |
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| Molecular Weight: | 85296.00 |
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| Species: | Toxoplasma gondii (strain ATCC 50861 / VEG) [432359] |
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| Number of TMSs: | 17 |
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| Substrate |
hydron |
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1: MGGRRRSFFL STAGALAPAV ATTTVSLIVL SSSFPLLSSS SPESEGDRFQ VTAATRDVPE
61: EASVAASREL SEEDATLRID KATTCLLLLP SIIGLFWAVY EAWKVSKIQM DGPLGDDNKR
121: LTDPLYLEMS GNIQQQLNMM KSISRCIADG AITFLTQEFK YMAVYIVVFS SILGIFVGIP
181: TMAAFVLGAL TSILCGFVGM KIAVYSNVRT CHEAWMELGR GFQVALTAGS VMGFALVSLG
241: CLTLVAIILL YRLPSLFGTN PEDQRALFEA VAGYGLGGSS IALFARVGGG IYTKAADVGA
301: DLSGKNEYGM SEDDPRNPAC IADNVGDNVG DVAGMGADLF GSLAEASCAG LVIAGASIAT
361: SASGGPQGLA HSWSGLMFPV LISSTGIFTG IFTVVLVRAC FSVRCYDDIE KALKWVMFIS
421: TGLEMPVLIL LSYFFLPSEF LLDGCQGTTA WWHAAVCVVL GLWAGLAIGY VTEYYTSHSY
481: FPVREISQTQ IVSAATGIIY GLALGYSSTV VPIICLGVTI LVSHTLCGMY GIALAALGML
541: STLTMGLMID GYGPISDNAG GIAEMAGLGP EVRSRTDALD AAGNTTAAVG KGYAIGSAAL
601: VSLALFGAFT VRAHITAVDV LDPWTFTGLL FGAMMPYAFS AMTMKSVGIA ASDMVQECLQ
661: QFPLIIQGNI EPQYKRCIEI STRASLHEMI APGALVICAP VAAGMMFGKN CTAGLLAGAL
721: VSGIQLAISA STSGSAWDNA KKYIESGALG ADHGKGSQAH KNAVTGDTVG DPLKDTSGPS
781: LNILIKLSAI ISLVFGAFIA EHFSNAQGGP AWVRVL