3.A.10.2.6
Vacuolar Ca2+-dependent H+ pumping pyrophosphatase, PPase or VP2, of 1057 aas and ~ 18 TMSs in a 2 + 1 + 2 + 5 + 10 TMS arrangement (Wunderlich 2022).
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| Accession Number: | Q8I570 |
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| Protein Name: | H(+)-exporting diphosphatase |
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| Length: | 1057 |
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| Molecular Weight: | 117106.00 |
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| Species: | Plasmodium falciparum (isolate 3D7) [36329] |
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| Number of TMSs: | 16 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
hydron, diphosphate(4-) |
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1: MVMLPLHENS STIRKKYKKN NKFFGGETSV KNFLERYSFT NKKDNKKNEK GTKLNILKYM
61: KLYMQKPVKH RITFNIIVFT LFLVIIYIFY HKIENIKTVF LISLTLYSLY FLLFSLYMLS
121: TILNDEYGDY NTLKKYDMTN NIYMNDNELN LINDKNDVQQ INNSQNNNDN YVHQMTNDHN
181: IQKKEIKKEY EKLKYDNHNN NENNLINPYN LEQNNQTFNQ HISNEYEKNN INLIHTKNTN
241: NDNKGDMKNE IGTNEGYEIS SFDSIGIPIK EGSEGFFTVQ YNSIFKISIV FTLLILSLYI
301: IRGEDTKLPQ GDNQMTDMMN NNNNNNNNNN NNSSSSNGTI IISSYAYGII TAISFLLGAL
361: CSSIAGYNGI YVAVRANVKV AKAATYSYKK ALITCFRSGA VSAIVNVALA IFGICSLLLL
421: VNILYPTLAF SKYPLLIVGY GFGASLVAML YQLAGGIYTK AADIGADLVG KVEKHIPEDD
481: PRNPAVIADL VGDNVGDCAG QCADLFESIC AEIIASMILG GNLSENGIIS EQTASYFVLF
541: PLFVHSMDLL ISTIGIYLVS VKNNNEPFST LNLECNTKII DKKDINYFNN INSNMHVEES
601: AMQPLNNNNK EESDLLYAKY DCDVTSEQLE NPLKAMLKAY FFTCSLGVVG FSFLCKLLFS
661: LDNAKNAWIY FSFCGFIGMA CSYLFVILTR YYTDYSYPKV KKIAHASLSG SATNIIAGLY
721: VGLESTFFPV IVISISLLLS YYLGLKSNIT GDHNIINGLY GTSVATMGML STAVFILSMS
781: NFGPIADNAG GIVEMCKQPK YVRVITDKLD AVGNVTKANT KGFSVGSAAL ACFLLFSAFL
841: SEVSVHSKMP FSTVDIAIPE VFIGGILGSV VVFLFAGWSL DAVGKTAEEV LKEVRRQFNE
901: HPGILTYKEK PDYHTCVAII SKRALIETIK PGLLGVLSPI IVGLIFKQLG ILQNNQLLGA
961: QAMASFIMFS TSTGILMALF LNNAGGAWDN AKKYIESGYY GGKNSQAHVS SVIGDTVGDP
1021: CKDTAGPSIH VLIKLISTIT MVITPLIAST TTKSVYS