3.A.10.3.2
Membrane-bound sodium- and potassium-regulated, proton-translocating pyrophosphatase of 806 aas. One report claims it transports only H+, not Na+ and that Na+ inhibits by competing with Mg2+ (Luoto et al. 2015), although a previous report claimed that it transports Na+ under normal physiological conditions, but protons if the Na+ concentration is low (Luoto et al. 2013).
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| Accession Number: | B3ECG7 |
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| Protein Name: | K(+)-insensitive pyrophosphate-energized proton pump |
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| Length: | 806 |
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| Molecular Weight: | 86765.00 |
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| Species: | Chlorobium limicola (strain DSM 245 / NBRC 103803) [290315] |
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| Number of TMSs: | 18 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
sodium(1+), hydron |
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1: MKKPFNVVRK AGAVMVSASL GVLLHAPKAM ASEADLVLPD LHSVSFLGGI PGDSLLLWGL
61: AICLFGMVFG AIQYMGIRKL PVHKAMREIS ELIYETCKTY LITQGKFILI LWVLIGAIIV
121: AYFGWLRQMP VDKVVFILVS SLIGILGSYT VAWFGMRINT FANSRTAFAS LGGKPFPTYA
181: IPLRAGMSIG MLLISIELFV MLCILLFVRP DYAGPCFIGF AIGESLGASV LRIAGGIFTK
241: IADIGSDLMK IVFKIKEDDA RNPGVIADCT GDNAGDSVGP TADGFETYGV TGVALISFIL
301: LAIKAPEVQI MLLVWIFAMR LVMILASAFS YWANAALAKM KYANADEMNF EKPLITLVWL
361: TSIVSIVLTY IASYYLISTL GDGTMWWKLA SIITCGTIAG ALIPELVNRF TSTECAHVRN
421: VVQCSKEGGA ALNILSGLVA GNFSAYWMGL AIISLMGAAY GVSTLGLDVM MLAPSVFAFG
481: LVAFGFLSMG PVTIAVDSYG PVTDNAQSVY ELSLIETLPN IRQSIQSEFG FQPDFDNAKR
541: YLEANDGAGN TFKATAKPVL IGTAVVGSTT MIFSIIMILT NGLADAAAIE KLSILSPPFL
601: LGLLMGGAVI YWFTGASINA VTTGAYYAVE FIKKNIRLEG VEKASVEDSK KVVEICTKFA
661: QKGMVNLFLT IFFSTLAFAC LDSFFFIGYL ISIALFGLYQ AIFMANAGGA WDNAKKVVET
721: ELHAKGTELH DASIVGDTVG DPFKDTSSVA LNPIIKFTTL FGLLAIELAI ELAPQVAMSL
781: AVVFFALSLL FVHRSFFSMR IKVDEH