3.A.10.3.3
Electrogenic H+-translocating Mg2+-pyrophosphatase, HhpA of 867 aas. Inhibited by Na+ and regulated by K+ as well (Luoto et al. 2015).
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| Accession Number: | F4H4X4 |
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| Protein Name: | K(+)-insensitive pyrophosphate-energized proton pump |
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| Length: | 867 |
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| Molecular Weight: | 91022.00 |
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| Species: | Cellulomonas fimi (strain ATCC 484 / DSM 20113 / JCM 1341 / NBRC 15513 / NCIMB 8980 / NCTC 7547) [590998] |
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| Number of TMSs: | 18 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
hydron |
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1: MSTSQSRSRV TSASPAAPPV DRPAARPRTP RSASRATAVG ALATLALLLS GCAATGEAGG
61: GSGHGGEAGL ALPDLGSVTI AGVPGRVWLG LGLVVCALGL AFGVTVVAQL KRLEVHDSMR
121: SVSELIYTTC KAYLVQQGRF LVVLWAFIAA VIVVYYRVLV GFDWGRVAVV IAFSLVGMAG
181: SYSVAWFGIR VNTYANSRTA FASLRGKALP LHRIPLRSGM AIGMVLISLE LAIMLVILLF
241: LPGDLAGACF IGFAVGESLG AAALRIAGGI FTKIADIGSD LMKIAFKIKE DDARNPGVIA
301: DCTGDNAGDS VGPSADGFET YGVTGVALVT FVLLGVPDPG VQAALLVWIF VVRTVMIAAS
361: GISYTVNDLV AQRRYAGAEG MDFEKPLTSL VWLTSAVCIV STYATTWLVL ADGTPGLWWK
421: LATIISCGTL AGALIPELVK VFTSTGSRHT REVVASSKEG GPSLNILSGL VAGNFSAYWL
481: GMTIVALMGG AYLVSELGLD EVMHAPAVFA FGLVAFGFLG MGPVTIAVDS YGPVTDNAQS
541: VYELSGVEDV DGIDEDLRAS HGFVPAWERA KQMLEENDGA GNTFKATAKP VLIGTAVVGA
601: TTMIFSIIMG LTDGLTTGLE NLSLLHPPFL LGLVAGGSVI YWFTGASIQA VTTGAYRAVE
661: FIRTHIRLDG SEKASEEDSR RVVEICTQYA QRGMLTMFLG VFFATLAFAF VEPYFFVGYL
721: ISIALFGLYQ AIFMANAGGA WDNAKKIVET ELHANGTPLH DATVVGDTVG DPFKDTSSVA
781: LNPVIKFTTL FGLLAVDLAV QLSGQGRHAL VLTLAAVFFL ASTYFVHRSF YGMRIQASTE
841: TPTPDDEPAE LLPQPGTPAD DAVPTRV