3.A.3.1.13
H+/K+-ATPase, ATP12A or ATP1AL1 of 1039 aas and 10 TMSs in a 2 + 2 + 6 TMS arrangement. It plays a role in myocardial relaxation (Knez et al. 2014), but also functions in airway surface liquid acidification which impaires airway host defenses in cells lacking or compromised for CFTR (TC# 3.A.1.202.1) (Shah et al. 2016). This non-gastric H+/K+ ATPase (ATP12A) is expressed in mammalian spermatozoa (Favia et al. 2022) and may be sodium ion sensitive (Abe et al. 2023). Its cryoEM structures are known, and the mechanism has been explained (Abe et al. 2023), providing insight into the molecular mechanism of the E2-E1 transition and cooperative Na+-binding in the NKA and other related cation pumps.
.
|
| Accession Number: | P54707 |
|---|
| Protein Name: | Potassium-transporting ATPase alpha chain 2 |
|---|
| Length: | 1039 |
|---|
| Molecular Weight: | 115511.00 |
|---|
| Species: | Homo sapiens (Human) [9606] |
|---|
| Number of TMSs: | 7 |
|---|
| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
|---|
| Substrate |
sodium(1+), potassium(1+) |
|---|
1: MHQKTPEIYS VELSGTKDIV KTDKGDGKEK YRGLKNNCLE LKKKNHKEEF QKELHLDDHK
61: LSNRELEEKY GTDIIMGLSS TRAAELLARD GPNSLTPPKQ TPEIVKFLKQ MVGGFSILLW
121: VGAFLCWIAY GIQYSSDKSA SLNNVYLGCV LGLVVILTGI FAYYQEAKST NIMSSFNKMI
181: PQQALVIRDS EKKTIPSEQL VVGDIVEVKG GDQIPADIRV LSSQGCRVDN SSLTGESEPQ
241: PRSSEFTHEN PLETKNICFY STTCLEGTVT GMVINTGDRT IIGHIASLAS GVGNEKTPIA
301: IEIEHFVHIV AGVAVSIGIL FFIIAVSLKY QVLDSIIFLI GIIVANVPEG LLATVTVTLS
361: LTAKRMAKKN CLVKNLEAVE TLGSTSIICS DKTGTLTQNR MTVAHLWFDN QIFVADTSED
421: HSNQVFDQSS RTWASLSKII TLCNRAEFKP GQENVPIMKK AVIGDASETA LLKFSEVILG
481: DVMEIRKRNR KVAEIPFNST NKFQLSIHEM DDPHGKRFLM VMKGAPERIL EKCSTIMING
541: EEHPLDKSTA KTFHTAYMEL GGLGERVLGF CHLYLPADEF PETYSFDIDA MNFPTSNLCF
601: VGLLSMIDPP RSTVPDAVTK CRSAGIKVIM VTGDHPITAK AIAKSVGIIS ANSETVEDIA
661: HRLNIAVEQV NKRDAKAAVV TGMELKDMSS EQLDEILANY QEIVFARTSP QQKLIIVEGC
721: QRQDAVVAVT GDGVNDSPAL KKADIGIAMG IAGSDAAKNA ADMVLLDDNF ASIVTGVEEG
781: RLIFDNLKKT IAYSLTKNIA ELCPFLIYII VGLPLPIGTI TILFIDLGTD IIPSIALAYE
841: KAESDIMNRK PRHKNKDRLV NQPLAVYSYL HIGLMQALGA FLVYFTVYAQ EGFLPRTLIN
901: LRVEWEKDYV NDLKDSYGQE WTRYQREYLE WTGYTAFFVG ILVQQIADLI IRKTRRNSIF
961: QQGLFRNKVI WVGITSQIII GLILSYGLGS VTALSFTMLR AQYWFVAVPH AILIWVYDEV
1021: RKLFIRLYPG SWWDKNMYY