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3.A.3.2.12 Endomembrane plasma membrane-type Ca²⁺ ATPase, ACA2 (Arabidopsis Ca²⁺ ATPase isoform 2) (lacks a C-terminal calmodulin domain, but activity is stimulated 5x by calmodulin which binds to an N-terminal inhibitory domain (Harper et al., 1998; Kamrul Huda et al. 2013).
Accession Number:	O81108
Protein Name:	Calcium-transporting ATPase 2, plasma membrane-type aka ACA2
Length:	1014
Molecular Weight:	110439.00
Species:	Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:	10
Location¹ / Topology² / Orientation³:	Endoplasmic reticulum membrane¹ / Multi-pass membrane protein²
Substrate	calcium(2+)

Structure:
RefSeq:	NP_195479.1
Entrez Gene ID:	829918
Pfam:	PF00689 PF00690 PF00122 PF00702
BioCyc:	MetaCyc:MONOMER-14659
KEGG:	ath:AT4G37640
Gene Ontology GO:0005789 C:endoplasmic reticulum membrane GO:0016021 C:integral to membrane GO:0005886 C:plasma membrane GO:0005524 F:ATP binding GO:0005388 F:calcium-transporting ATPase activity GO:0005516 F:calmodulin binding GO:0046872 F:metal ion binding GO:0006754 P:ATP biosynthetic process GO:0006816 P:calcium ion transport
References (4) [1] “A novel calmodulin-regulated Ca2+-ATPase (ACA2) from Arabidopsis with an N-terminal autoinhibitory domain.” Harper J.F.et.al. 9422775 [2] “Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.” Mayer K.F.X.et.al. 10617198 [3] “Empirical analysis of transcriptional activity in the Arabidopsis genome.” Yamada K.et.al. 14593172 [4] “A calcium-dependent protein kinase can inhibit a calmodulin-stimulated Ca2+ pump (ACA2) located in the endoplasmic reticulum of Arabidopsis.” Hwang I.et.al. 10823962
2M7E

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MESYLNENFD VKAKHSSEEV LEKWRNLCGV VKNPKRRFRF TANLSKRYEA AAMRRTNQEK 
61:	LRIAVLVSKA AFQFISGVSP SDYTVPEDVK AAGFEICADE LGSIVESHDV KKLKFHGGVD 
121:	GLAGKLKASP TDGLSTEAAQ LSQRQELFGI NKFAESEMRG FWVFVWEALQ DMTLMILGVC 
181:	AFVSLIVGIA TEGWPKGSHD GLGIAASILL VVFVTATSDY RQSLQFRDLD KEKKKITVQV 
241:	TRNGFRQKLS IYDLLPGDIV HLAIGDQVPA DGLFLSGFSV VIDESSLTGE SEPVMVNAQN 
301:	PFLMSGTKVQ DGSCKMMITT VGMRTQWGKL MATLTEGGDD ETPLQVKLNG VATIIGKIGL 
361:	FFAVVTFAVL VQGMFMRKLS TGTHWVWSGD EALELLEYFA IAVTIVVVAV PEGLPLAVTL 
421:	SLAFAMKKMM NDKALVRHLA ACETMGSATT ICSDKTGTLT TNHMTVVKSC ICMNVQDVAN 
481:	KGSSLQSEIP ESAVKLLIQS IFNNTGGEVV VNKHGKTELL GTPTETAILE LGLSLGGKFQ 
541:	EERKSYKVIK VEPFNSTKKR MGVVIELPEG GRMRAHTKGA SEIVLAACDK VVNSSGEVVP 
601:	LDEESIKYLN VTINEFANEA LRTLCLAYMD IEGGFSPDDA IPASGFTCVG IVGIKDPVRP 
661:	GVKESVELCR RAGITVRMVT GDNINTAKAI ARECGILTDD GIAIEGPVFR EKNQEELLEL 
721:	IPKIQVMARS SPMDKHTLVK QLRTTFDEVV AVTGDGTNDA PALHEADIGL AMGIAGTEVA 
781:	KESADVIILD DNFSTIVTVA KWGRSVYINI QKFVQFQLTV NVVALVVNFS SACLTGSAPL 
841:	TAVQLLWVNM IMDTLGALAL ATEPPNDELM KRLPVGRRGN FITNAMWRNI LGQAVYQFIV 
901:	IWILQAKGKA MFGLDGPDST LMLNTLIFNC FVFCQVFNEI SSREMEEIDV FKGILDNYVF 
961:	VVVIGATVFF QIIIIEFLGT FASTTPLTIT QWIFSIFIGF LGMPIAAGLK TIPV

3.A.3.2.12
Endomembrane plasma membrane-type Ca²⁺ ATPase, ACA2 (Arabidopsis Ca²⁺ ATPase isoform 2) (lacks a C-terminal calmodulin domain, but activity is stimulated 5x by calmodulin which binds to an N-terminal inhibitory domain (Harper et al., 1998; Kamrul Huda et al. 2013).

Cross database links:

Gene Ontology

References (4)

External Searches:

Analyze:

3.A.3.2.12Endomembrane plasma membrane-type Ca2+ ATPase, ACA2 (Arabidopsis Ca2+ ATPase isoform 2) (lacks a C-terminal calmodulin domain, but activity is stimulated 5x by calmodulin which binds to an N-terminal inhibitory domain (Harper et al., 1998; Kamrul Huda et al. 2013).

Cross database links:

Gene Ontology

References (4)

External Searches:

Analyze:

3.A.3.2.12
Endomembrane plasma membrane-type Ca²⁺ ATPase, ACA2 (Arabidopsis Ca²⁺ ATPase isoform 2) (lacks a C-terminal calmodulin domain, but activity is stimulated 5x by calmodulin which binds to an N-terminal inhibitory domain (Harper et al., 1998; Kamrul Huda et al. 2013).