3.A.3.2.31
Sarcoplasmic reticulum Ca2+ ATPase, Atp6. The inhibitors, artemisinin and its anti-malarial derivatives, artesunate and artemether, bind to a hydrophobic pocket in a transmembrane region near the membrane surface (Naik et al. 2011; Meier et al. 2018). Other inhibitors include arterolane and thapsigargin (Meier et al. 2018).
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| Accession Number: | Q08853 |
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| Protein Name: | Calcium-transporting ATPase |
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| Length: | 1228 |
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| Molecular Weight: | 139415.00 |
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| Species: | Plasmodium falciparum (isolate K1 / Thailand) [5839] |
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| Number of TMSs: | 10 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
calcium(2+) |
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1: MEEVIKNAHT YDVEDVLKFL DVNKDNGLKN EELDDRRLKY GLNELEVEKK KSIFELILNQ
61: FDDLLVKILL LAAFISFVLT LLDMKHKKIE ICDFIEPLVI VLILILNAAV GVWQECNAEK
121: SLEALKELQP TKAKVLRDGK WEIIDSKYLY VGDIIELSVG NKTPADARII KIYSTSLKVE
181: QSMLTGESCS VDKYAEKMED SYKNCEIQLK KNILFSSTAI VCGRCIAVVI NIGMKTEIGH
241: IQHAVIESNS EDTQTPLQIK IDLFGQQLSK IIFVICVTVW IINFKHFSDP IHGSFLYGCL
301: YYFKISVALA VAAIPEGLPA VITTCLALGT RRMVKKNAIV RKLQSVETLG CTTVICSDKT
361: GTLTTNQMTT TVFHLFRESD SLTEYQLCQK GDTYYFYESS NLTNDIYAGE SSFFNKLKDE
421: GNVEALTDDG EEGSIDEADP YSDYFSSDSK KMKNDLNNNN NNNNNSSRSG AKRNIPLKEM
481: KSNENTIISR GSKILEDKIN KYCYSEYDYN FYMCLVNCNE ANIFCNDNSQ IVKKFGDSTE
541: LALLHFVHNF DILPTFSKNN KMPAEYEKNT TPVQSSNKKD KSPRGINKFF SSKNDNSHIT
601: STLNENDKNL KNANHSNYTT AQATTNGYEA IGENTFEHGT SFENCFHSKL GNKINTTSTH
661: NNNNNNNNNS NSVPSECISS WRNECKQIKI IEFTRERKLM SVIVENKKKE IILYCKGAPE
721: NIIKNCKYYL TKNDIRPLNE TLKNEIHNKI QNMGKRALRT LSFAYKKLSS KDLNIKNTDD
781: YYKLEQDLIY LGGLGIIDPP RKYVGRAIRL CHMAGIRVFM ITGDNINTAR AIAKEINILN
841: KNEGDDEKDN YTNNKNTQIC CYNGREFEDF SLEKQKHILK NTPRIVFCRT EPKHKKQIVK
901: VLKDLGETVA MTGDGVNDAP ALKSADIGIA MGINGTEVAK EASDIVLADD NFNTIVEAIK
961: EGRCIYNNMK AFIRYLISSN IGEVASIFIT ALLGIPDSLA PVQLLWVNLV TDGLPATALG
1021: FNPPEHDVMK CKPRHKNDNL INGLTLLRYI IIGTYVGIAT VSIFVYWFLF YPDSDMHTLI
1081: NFYQLSHYNQ CKAWNNFRVN KVYDMSEDHC SYFSAGKIKA STLSLSVLVL IEMFNALNAL
1141: SEYNSLFEIP PWRNMYLVLA TIGSLLLHVL ILYIPPLARI FGVVPLSAYD WFLVFLWSFP
1201: VIILDEIIKF YAKRKLKEEQ RTKKIKID