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3.A.3.2.9 Ca²⁺,Mn²⁺-ATPase, hSPCA2 (ATP2C2) (efflux). 64% identical to hSPCA1 (TC #3.A.3.2.5) but lower affinity for Ca²⁺ and more restricted tissue distribution (brain and testis); present in the trans-Golgi network. May function in Mn²⁺ detoxification (Xiang et al., 2005).
Accession Number:	O75185
Protein Name:	Calcium-transporting ATPase
Length:	946
Molecular Weight:	103187.00
Species:	Homo sapiens (Human) [9606]
Number of TMSs:	10
Location¹ / Topology² / Orientation³:	Membrane¹ / Multi-pass membrane protein²
Substrate	calcium(2+), manganese(2+)

RefSeq:	NP_055676.2
Entrez Gene ID:	9914
Pfam:	PF00689 PF00690 PF00122 PF00702
OMIM:	613082 gene
KEGG:	hsa:9914
Gene Ontology GO:0016021 C:integral to membrane GO:0005524 F:ATP binding GO:0005388 F:calcium-transporting ATPase activity GO:0046872 F:metal ion binding GO:0006754 P:ATP biosynthetic process GO:0006816 P:calcium ion transport
References (6) [1] “The secretory pathway Ca2+/Mn2+-ATPase 2 is a Golgi-localized pump with high affinity for Ca2+ ions.” Vanoevelen J.et.al. 15831496 [2] “Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.” Ishikawa K.et.al. 9734811 [3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [4] “The full-ORF clone resource of the German cDNA consortium.” Bechtel S.et.al. 17974005 [5] “The sequence and analysis of duplication-rich human chromosome 16.” Martin J.et.al. 15616553 [6] “A quantitative atlas of mitotic phosphorylation.” Dephoure N.et.al. 18669648

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CDD Search (Conserved Domain Database)

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FASTA formatted sequence

1:	MVEGRVSEFL KKLGFSGGGR QYQALEKDEE EALIDEQSEL KAIEKEKKVT ALPPKEACKC 
61:	QKEDLARAFC VDLHTGLSEF SVTQRRLAHG WNEFVADNSE PVWKKYLDQF KNPLILLLLG 
121:	SALVSVLTKE YEDAVSIATA VLVVVTVAFI QEYRSEKSLE ELTKMVPPEC NCLREGKLQH 
181:	LLARELVPGD VVSLSIGDRI PADIRLTEVT DLLVDESSFT GEAEPCSKTD SPLTGGGDLT 
241:	TLSNIVFMGT LVQYGRGQGV VIGTGESSQF GEVFKMMQAE ETPKTPLQKS MDRLGKQLTL 
301:	FSFGIIGLIM LIGWSQGKQL LSMFTIGVSL AVAAIPEGLP IVVMVTLVLG VLRMAKKRVI 
361:	VKKLPIVETL GCCSVLCSDK TGTLTANEMT VTQLVTSDGL RAEVSGVGYD GQGTVCLLPS 
421:	KEVIKEFSNV SVGKLVEAGC VANNAVIRKN AVMGQPTEGA LMALAMKMDL SDIKNSYIRK 
481:	KEIPFSSEQK WMAVKCSLKT EDQEDIYFMK GALEEVIRYC TMYNNGGIPL PLTPQQRSFC 
541:	LQEEKRMGSL GLRVLALASG PELGRLTFLG LVGIIDPPRV GVKEAVQVLS ESGVSVKMIT 
601:	GDALETALAI GRNIGLCNGK LQAMSGEEVD SVEKGELADR VGKVSVFFRT SPKHKLKIIK 
661:	ALQESGAIVA MTGDGVNDAV ALKSADIGIA MGQTGTDVSK EAANMILVDD DFSAIMNAVE 
721:	EGKGIFYNIK NFVRFQLSTS ISALSLITLS TVFNLPSPLN AMQILWINII MDGPPAQSLG 
781:	VEPVDKDAFR QPPRSVRDTI LSRALILKIL MSAAIIISGT LFIFWKEMPE DRASTPRTTT 
841:	MTFTCFVFFD LFNALTCRSQ TKLIFEIGFL RNHMFLYSVL GSILGQLAVI YIPPLQRVFQ 
901:	TENLGALDLL FLTGLASSVF ILSELLKLCE KYCCSPKRVQ MHPEDV

3.A.3.2.9
Ca²⁺,Mn²⁺-ATPase, hSPCA2 (ATP2C2) (efflux). 64% identical to hSPCA1 (TC #3.A.3.2.5) but lower affinity for Ca²⁺ and more restricted tissue distribution (brain and testis); present in the trans-Golgi network. May function in Mn²⁺ detoxification (Xiang et al., 2005).

Cross database links:

Gene Ontology

References (6)

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3.A.3.2.9Ca2+,Mn2+-ATPase, hSPCA2 (ATP2C2) (efflux). 64% identical to hSPCA1 (TC #3.A.3.2.5) but lower affinity for Ca2+ and more restricted tissue distribution (brain and testis); present in the trans-Golgi network. May function in Mn2+ detoxification (Xiang et al., 2005).

Cross database links:

Gene Ontology

References (6)

External Searches:

Analyze:

3.A.3.2.9
Ca²⁺,Mn²⁺-ATPase, hSPCA2 (ATP2C2) (efflux). 64% identical to hSPCA1 (TC #3.A.3.2.5) but lower affinity for Ca²⁺ and more restricted tissue distribution (brain and testis); present in the trans-Golgi network. May function in Mn²⁺ detoxification (Xiang et al., 2005).