Search TCDB: (?)
TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


3.A.3.4.1
Mg2+/Ni2+-ATPase (uptake) of 902 aas and 10 TMSs in a 2 + 2 + 6 TMS arrangement.  The structure of the Mg2+ transporter MgtA, solved by single particle cryo-electron microscopy (cryo-EM), high resolution structures of both a homodimeric form (2.9 Å), the first for a P-type ATPase, and a monomeric form (3.6 Å). Each monomeric unit of MgtA displays a structural architecture that is similar to other P-type ATPases with a transmembrane domain and two soluble domains. The dimer interface consists of contacts between residues in adjacent soluble nucleotide binding and phosphotransfer regions of the haloacid dehalogenase (HAD) domain (Zeinert et al. 2024).

Accession Number:P36640
Protein Name:ATMA aka MgtA aka STM4456
Length:902
Molecular Weight:99783.00
Species:Salmonella typhimurium [90371]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate magnesium(2+), nickel(2+)

Cross database links:

RefSeq: NP_463316.1   
Entrez Gene ID: 1255982   
Pfam: PF00690    PF00122    PF00702   
BioCyc: STYP99287:STM4456-MONOMER   
KEGG: stm:STM4456   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005524 F:ATP binding
GO:0015444 F:magnesium-importing ATPase activity
GO:0046872 F:metal ion binding
GO:0006754 P:ATP biosynthetic process
GO:0015693 P:magnesium ion transport

References (2)

[1] “Magnesium transport in Salmonella typhimurium: mgtA encodes a P-type ATPase and is regulated by Mg2+ in a manner similar to that of the mgtB P-type ATPase.”  Tao T.et.al.   7751273
[2] “Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.”  McClelland M.et.al.   11677609

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MLKIITRQLF ARLNRHLPYR LVHRDPLPGA QTAVNATIPP SLSERCLKVA AMEQETLWRV 
61:	FDTHPEGLNA AEVTRAREKH GENRLPAQKP SPWWVHLWVC YRNPFNILLT ILGGISYATE 
121:	DLFAAGVIAL MVGISTLLNF VQEARSTKAA DALKAMVSNT ATVLRVINEN GENAWLELPI 
181:	DQLVPGDIIK LAAGDMIPAD LRIIQARDLF VAQASLTGES LPVEKVAATR EPRQNNPLEC 
241:	DTLCFMGTNV VSGTAQAVVM ATGAGTWFGQ LAGRVSEQDN EQNAFQKGIS RVSMLLIRFM 
301:	LVMAPVVLII NGYTKGDWWE AALFALSVAV GLTPEMLPMI VTSTLARGAV KLSKQKVIVK 
361:	HLDAIQNFGA MDILCTDKTG TLTQDKIVLE NHTDISGKPS EHVLHCAWLN SHYQTGLKNL 
421:	LDTAVLEGVD ETAARQLSGR WQKIDEIPFD FERRRMSVVV AEDSNVHQLV CKGALQEILN 
481:	VCTQVRHNGD IVPLDDNMLR RVKRVTDTLN RQGLRVVAVA TKYLPAREGD YQRIDESDLI 
541:	LEGYIAFLDP PKETTAPALK ALKASGITVK ILTGDSELVA AKVCHEVGLD AGDVIIGSDI 
601:	EGLSDDALAA LAARTTLFAR LTPMHKERIV TLLKREGHVV GFMGDGINDA PALRAADIGI 
661:	SVDGAVDIAR EAADIILLEK SLMVLEEGVI EGRRTFSNML KYIKMTASSN FGNVFSVLVA 
721:	SAFLPFLPML PLHLLIQNLL YDVSQVAIPF DNVDEEQIQK PQRWNPADLG RFMVFFGPIS 
781:	SIFDILTFCL MWWVFHANTP ETQTLFQSGW FVVGLLSQTL IVHMIRTRRL PFIQSRAAWP 
841:	LMAMTLLVMV VGVSLPFSPL ASYLQLQALP LSYFPWLIAI LVGYMTLTQL VKGFYSRRYG 
901:	WQ