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3.A.3.5.15
The transferable, plasmid-localized, copper sensitivity (uptake) ATPase, TcrA (811aas) (46% identical to 3.A.3.5.1) (Hasman, 2005)

Accession Number:Q3MNJ6
Protein Name:Cation-transporting ATPase aka TcrA)
Length:811
Molecular Weight:86816.00
Species:Enterococcus faecium (Streptococcus faecium) [1352]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate copper(1+)

Cross database links:

Pfam: PF00122    PF00403    PF00702   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0005507 F:copper ion binding
GO:0004008 F:copper-exporting ATPase activity
GO:0006754 P:ATP biosynthetic process
GO:0006825 P:copper ion transport

References (2)

[1] “tcrB, a gene conferring transferable copper resistance in Enterococcus faecium: occurrence, transferability, and linkage to macrolide and glycopeptide resistance.”  Hasman H.et.al.   11959576
[2] “The tcrB gene is part of the tcrYAZB operon conferring copper resistance in Enterococcus faecium and Enterococcus faecalis.”  Hasman H.et.al.   16151212

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTCASCAQTV EKAAKKVRGV TQASVNLATE KLSIEYDEPT FSVENLQKAV DNSGYELIAQ 
61:	EGTTQTFAIE GMTCASCAQT IEKAVGKLSG VDKASVNLAT EKMQVSYNPS AISVSDVTGA 
121:	VSNSGYAAVL ETTETQDNSR AEKREKKEKR MKQLSNRFGI SIIFTIPLLI ISMGPMVGMP 
181:	LPNIVDPMIN AFNFSLLQLI LTLPIMVVSW EYFQKGFKTL FKGHPNMDSL IALGTAAAFV 
241:	YSLAATIGAG LGYGNFSDLL YYEVTGVILT LHTLGLFLEE RSKGQMSSAI EKLVNLVPKT 
301:	ARVIRNGVEQ EITVDEVALG DVIRVRPGES MPVDGVVVEG RTSVDESMLT GESIPVEKES 
361:	GDEVIGASIN KNGSIDYRAT RVGSDTTLSQ IIKLVEDAQG SKAPIARMAD IITRYFVPIV 
421:	IALAVLAGIA WLIAGQSGIF ILSVIITTLV IACPCALGLA TPTSIMVGTG KGAEHGVLIK 
481:	SGEALETTHN LDTIVFDKTG TLTEGKPIVT DILVTPLITK ENLLYYAASG ETGSEHPLGE 
541:	AIVQKSKEEN MTLAKPDHFE AIPGHGIRVE IEGKDMYIGN RKLMLEQKID LSSMEKESNR 
601:	LADEGKTPMY LSVDGELAGI IAVADTLKEN SMKAVKELRR RGVEVIMITG DNKRTAKAIA 
661:	KQVGIDSVLS EVLPEDKAEE VKKLQEAGKK VAMVGDGIND APALAQADIG IAVGSGTDVA 
721:	IESADIVLMR NDLTAVLTAI DLSHATLRNI KQNLFWAFAY NLVGIPVAMG LLYIFGGPLM 
781:	NPMFAAVAMS FSSVSVLLNA LRLRRFKPAV V