3.A.3.5.37
Copper exporting ATPase, ATP7 of 1254 aas and 10 - 12 TMSs. DmATP7 is the sole Drosophila melanogaster ortholog of the human MNK and WND copper transporters. A regulatory element drives expression in all neuronal tissues examined and demonstrates copper-inducible, Mtf-1-dependent expression in the larval midgut. Thus, an important functional role for copper transport in neuronal tissues is implied. Regulation of DmATP7 expression is not used to limit copper absorption under toxic copper conditions. The protein localizes to the basolateral membrane of DmATP7 expressing midgut cells, supporting a role in export of copper from midgut cells (Burke et al. 2008).
|
| Accession Number: | Q9VYT4 |
|---|
| Protein Name: | ATP7, isoform B |
|---|
| Length: | 1254 |
|---|
| Molecular Weight: | 136082.00 |
|---|
| Species: | Drosophila melanogaster (Fruit fly) [7227] |
|---|
| Number of TMSs: | 11 |
|---|
| Location1 / Topology2 / Orientation3: |
Membrane1 |
|---|
| Substrate |
copper cation |
|---|
1: MPSDERVEAT MSTVRLPIVG MTCQSCVRNI TEHIGQKSGI LGVRVILEEN AGYFDYDPRQ
61: TDPARIASDI DDMGFECSYP GDAADPPETP ASAWTNIRVV GMTCQSCVRN IEGNIGTKPG
121: IHSIEVQLAA KNARVQYDPA QYDPAQIAEL IDDMGFEASV QEPRSPSQSP SPAPASSPKK
181: RATPTPPPPS YAQNGSAVAI PVEQELLTKC FLHIRGMTCA SCVAAIEKHC KKIYGLDSIL
241: VALLAAKAEV KFNANVVTAE NIAKSITELG FPTELIDEPD NGEAEVELEI MGMTCASCVN
301: KIESHVLKIR GVTTASVTLL TKRGKFRYIT EETGPRSICE AIEALGFEAK LMTGRDKMAH
361: NYLEHKEEIR KWRNAFLVSL IFGGPCMVAM IYFMLEMSDK GHANMCCLVP GLSMENLVMF
421: LLSTPVQFFG GFHFYVQSYR AIKHGTTNMD VLISMVTTIS YVYSVAVVIA AVLLEQNSSP
481: LTFFDTPPML LIFISLGRWL EHIAKGKTSE ALSKLLSLKA ADALLVEISP DFDIISEKVI
541: SVDYVQRGDI LKVIPGAKVP VDGKVLYGHS SCDESLITGE SMPVAKRKGS VVIGGSINQN
601: GVLLVEATHT GENTTLAQIV RLVEEAQTSK APIQQLADRI AGYFVPFVVV VSSITLIAWI
661: IIGFSNPNLV PVAMEHKMHM DQNTIIVSYA FKCALSVLAI ACPCALGLAT PTAVMVATGT
721: GAINGVLVKG ATALENAHKV KTVVFDKTGT ITHGTPMTSK VTLFVTAQVC SLARALTIVG
781: AAEQNSEHPI ASAIVHFAKD MLNVGATPQA GSFGKSSHFQ AVPGCGIRVT VSNYEQTLRQ
841: ACNADRIINY ENLHRTHPQG SVPVDNGASI EHLLPQRSVR KSMELNNQQL LSDLVLEPEE
901: ELLTDQKIID SPEILVLIGN REWMERNAIE VPLEISDCMT HEERKGHTAV LCALNGQLVC
961: MFAVSDMVKP EAHLAVYTLK RMGIDVVLLT GDNKNTAASI AREVGIRTVY AEVLPSHKVA
1021: KIQRIQANGI RVAMVGDGVN DSPALAQADV GITIAAGTDV AAEASDIVLM RNDLLDVVAC
1081: LDLSRCTVRR IRYNFFFASM YNLLGIPLAS GLFAPYGFTL LPWMASVAMA ASSVSVVCSS
1141: LLLKMYRKPT AKTLRTAEYE AQLAAERASG SEDELDKLSL HRGLDDLPEK GRMPFKRSST
1201: SLISRIFMHD YGNITSPDAK YGEGLLDPEE QYDGRTKIVR SRFHANDSTE LQKL