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3.A.3.6.20
Cadmium/zinc-transporting (heavy metal-resistance) ATPase 3, HMA3, of 760 aas and probably 8 TMSs in a 2 (~residue 20) + 2 (~ residue 120) +2 (~ residue 320) + 2 (~ residue 670).  Variations in the tonoplast cadmium transporter heavy metal ATPase 3 (HMA3) homolog gene/protein in wild and domesticateds strains of Aegilops tauschii, the precursor of wheat, have been characterized (Li et al. 2023).

Accession Number:P0CW78
Protein Name:Cadmium/zinc-transporting ATPase HMA3
Length:760
Molecular Weight:81856.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Vacuole membrane1 / Multi-pass membrane protein2
Substrate cadmium(2+), zinc(2+)

Cross database links:

Pfam: PF00122    PF00702   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005774 C:vacuolar membrane
GO:0005524 F:ATP binding
GO:0008551 F:cadmium-exporting ATPase activity
GO:0046872 F:metal ion binding
GO:0016463 F:zinc-exporting ATPase activity
GO:0006754 P:ATP biosynthetic process

References (2)

[1] “AtHMA3, a plant P(1B)-ATPase, functions as a Cd/Pb transporter in yeast.”  Gravot A.et.al.   15013746
[2] “P-type ATPase heavy metal transporters with roles in essential zinc homeostasis in Arabidopsis.”  Hussain D.et.al.   15100400

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MAEGEESKKM NLQTSYFDVV GICCSSEVSI VGNVLRQVDG VKEFSVIVPS RTVIVVHDTF 
61:	LISPLQIVKA LNQARLEASV RPYGETSLKS QWPSPFAIVS GVLLVLSFFK YFYSPLEWLA 
121:	IVAVVAGVFP ILAKAVASVT RFRLDINALT LIAVIATLCM QDFTEAATIV FLFSVADWLE 
181:	SSAAHKASIV MSSLMSLAPR KAVIADTGLE VDVDEVGINT VVSVKAGESI PIDGVVVDGS 
241:	CDVDEKTLTG ESFPVSKQRE STVMAATINL NGYIKVKTTA LARDCVVAKM TKLVEEAQKS 
301:	QTKTQRFIDK CSRYYTPAVV VSAACFAVIP VLLKVQDLSH WFHLALVVLV SGCPCGLILS 
361:	TPVATFCALT KAATSGFLIK TGDCLETLAK IKIVAFDKTG TITKAEFMVS DFRSLSPSIN 
421:	LHKLLNWVSS IECKSSHPMA AALIDYAISV SVEPKPDIVE NFQNFPGEGV YGRIDGQDIY 
481:	IGNKRIAQRA GCLTDNVPDI EATMKRGKTI GYIYMGAKLT GSFNLLDGCR YGVAQALKEL 
541:	KSLGIQTAML TGDNQDAAMS TQEQLENALD IVHSELLPQD KARIIDDFKI QGPTMMVGDG 
601:	LNDAPALAKA DIGISMGISG SALATETGDI ILMSNDIRKI PKGMRLAKRS HKKVIENVVL 
661:	SVSIKGAIMV LGFVGYPLVW AAVLADAGTC LLVILNSMIL LRDEREAVST CYRSSTSSPV 
721:	KLEEDEVEDL EVGLLQKSEE TSKKSCCSGC CSGPKDNQQK