3.A.3.6.25
Cd2+/Zn2+/Co2+ export ATPase, ZntA, of 904 aas and 8 TMSs. Expression of the zntA gene is inducible by all three metal ions, with Cd2+ being the most potent, mediated by the MerR-like regulator, ZntR (Chaoprasid et al. 2015). zntA and zntR mutants
were highly sensitive to CdCl2 and ZnCl2, and less sensitive to CoCl2. Inactivation of zntA increased the accumulation of
intracellular cadmium and zinc and conferred hyper-resistance to H2O2.
Thus, ZntA and its regulator, ZntR, are important
for controlling zinc homeostasis and cadmium and cobalt detoxification.
The loss of either the zntA or zntR gene did not affect the virulence of A. tumefaciens in Nicotiana benthamiana (Chaoprasid et al. 2015).
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| Accession Number: | F7U6A3 |
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| Protein Name: | P type cation (Metal) transporter, ATPase component |
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| Length: | 904 |
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| Molecular Weight: | 94906.00 |
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| Species: | Agrobacterium tumefaciens F2 [1050720] |
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| Number of TMSs: | 8 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 |
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| Substrate |
cadmium(2+), cobalt(2+), zinc(2+) |
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1: MNISTRGNLN GQSEDLTFTV GGMDCGSCAA KIETALSRLP GVADVKVSVA RERLNLSLAD
61: NKTSVEKIED TLRKLGFKPA LLPQDKAPRE KAAAEHHEHA HDHGDDHDHS SCGGHHPAEA
121: APSVEQNNAL TFSVGGMDCG SCAAKIETAL SRLPGVADVK VSVARERLNL SLAESKTPVE
181: KIEDTLRKLG FKPALLPQEK SAREKVDDHG HDHGSCSGHD HNHDHSGHDH SGHDHSAHDH
241: SDHDHANCGG HDHDHAKHSH EKAQTATATQ SAEVGHAHGA DEKGVWWRTA KARNTFTGTL
301: LVAVAYAAEL SFPSWGSYAF IIATLVTLFP IARNAFNAAR FGAIFTIEML MTIAAIGAIF
361: IGEAEEAAIV VLLFSVGELL EGFAAARARS GIKALGSLLP KTALVEENGS LRQVAADQVR
421: IGQVVVARPG DRIAADGVVM EGESSVDESP MTGESIPVAK EKGARVFAGS INHDGSLRIR
481: VDRAPEDNTI ARIITLVEEA QDARAPTERF IQNFSRYYMP LIVAISVLTI IVPPLAGLGD
541: WDTWIYRGLA LLLIGCPCAL VISVPAAIAS SLSAAARHGM LVKGGAVIEM LARTETVAFD
601: KTGTLTLGEP VVTDVVALDG DENTLIAQAA TIEHESSHPL ARAIVNHAEK AGVKPLPGSN
661: IKAISGRGMQ GTVGGKDLFI GAPRFATEVG TLSKDLADRI SALESEGKTV AVVMAGGAAS
721: GLFAMRDEPR KDAAEGIKAL KDMGISSLML SGDNARTARA IGNKLGLEAR GELLPQNKVE
781: EIRKLAAQKT VVMVGDGIND APALAAASVG VAIGSGTDVA MEAADAALMR NNVGDAARLI
841: GLSRATMANI RQNVTIALGL KAVFLVTTVT GLSGLWLAVF ADTGATVLVT ANAMRLLGYF
901: KKSA