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3.A.3.6.27 Transition metal efflux ATPase of 829 aas and 6 TMSs, CzcP. Exports Zn²⁺, Cd²⁺ and Co²⁺ efficiently (Scherer and Nies 2009). The side chains of Met254, Cys476, and His807 contribute to Cd²⁺, Co²⁺, and Zn²⁺ binding and transport (Smith et al. 2017).
Accession Number:	Q1LAJ7
Protein Name:	CzcP cation efflux P1-ATPase
Length:	829
Molecular Weight:	86994.00
Species:	Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34) [266264]
Number of TMSs:	6
Location¹ / Topology² / Orientation³:	Cell membrane¹
Substrate	cadmium(2+), cobalt(2+), zinc(2+)

Structure:
4U9R

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

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FASTA formatted sequence

1:	MTEKLRLDIP VLLPGLPDSS DPCVERLLSE LRGKEGVEAA HIKTANVDSD SQICVHYDPA 
61:	AISLARIREL VTSTGAVISS RFGHVLWQLK GVWHERRART VASQLRALPG VIEAEVSASG 
121:	IARVEFDNDR ISAAGIEQAL SKRGLAPVEI GARKSGHADH EHREGVKDHA HGEGEGHEAH 
181:	AHGSVFGPNT ELIFSLICGA LLGLGFAVGK LFGSLPAWIP VAFFVGAYFF GGFYTVREAI 
241:	ENLRLKKFEI DTLMLVAAAG AAALGAWAEG ALLLFLFSLG HGLEHYAMGR AKRAIEALAA 
301:	LAPATASVRR EGEVREVPVE ELQVGDVVVV RPNERLPADG FLVKGASAVN QAPVTGESIP 
361:	VDKQPVDDAA AARRKPDAVG AVSRVFAGTI NGAGAIEVEV TRLSTDSALA KVVKMVNEAE 
421:	AQKSPSQRFT EKFERIFVPA VLVLAVLLLF AGLVINEPFS ATFYRAMAVL VAASPCALAI 
481:	ATPSAVLSGV ARAARGGVLI KGGAPLENLG SLKAIAFDKT GTLTEGRPRI TDVMVAEGVA 
541:	EAELLSVAVA VESLSDHPLA AAIARDGRKR LEGSSIPEAS HLQSLTGRGV TATLCGKTVW 
601:	IGKPDMFGAD GIAPLSESMA SAVQTLRSTG RTTMIVRQGD RDLGAIGLMD TPRASARAAL 
661:	EALRRLGITR MIMISGDHQR AAEAVAKDVG IDEAWGDLMP EDKVKAIQTL RAEAKVAMVG 
721:	DGVNDAPAMA NATVGIAMGA AGSDVALETA DVALMADDLQ HLPFVVGLSR HTRAIILQNV 
781:	YISLGVVAFL LPATILGLGI GPAVAMHEGS TLIVVFNALR LLAYRDKSP

3.A.3.6.27
Transition metal efflux ATPase of 829 aas and 6 TMSs, CzcP. Exports Zn²⁺, Cd²⁺ and Co²⁺ efficiently (Scherer and Nies 2009). The side chains of Met254, Cys476, and His807 contribute to Cd²⁺, Co²⁺, and Zn²⁺ binding and transport (Smith et al. 2017).

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3.A.3.6.27Transition metal efflux ATPase of 829 aas and 6 TMSs, CzcP. Exports Zn2+, Cd2+ and Co2+ efficiently (Scherer and Nies 2009). The side chains of Met254, Cys476, and His807 contribute to Cd2+, Co2+, and Zn2+ binding and transport (Smith et al. 2017).

Cross database links:

External Searches:

Analyze:

3.A.3.6.27
Transition metal efflux ATPase of 829 aas and 6 TMSs, CzcP. Exports Zn²⁺, Cd²⁺ and Co²⁺ efficiently (Scherer and Nies 2009). The side chains of Met254, Cys476, and His807 contribute to Cd²⁺, Co²⁺, and Zn²⁺ binding and transport (Smith et al. 2017).