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| Accession Number: | Q59465 |
| Protein Name: | HMCT aka CadA aka HP0791 |
| Length: | 686 |
| Molecular Weight: | 75012.00 |
| Species: | Helicobacter pylori (Campylobacter pylori) [210] |
| Number of TMSs: | 7 |
| Location1 / Topology2 / Orientation3: | Cell membrane1 / Multi-pass membrane protein2 |
| Substrate | cadmium(2+), cobalt(2+), zinc(2+) |
Cross database links:
| DIP: | DIP-3082N |
|---|---|
| RefSeq: | NP_207584.1 |
| Entrez Gene ID: | 899347 |
| Pfam: | PF00122 PF00403 PF00702 |
| KEGG: | hpy:HP0791 |
Gene Ontology
GO:0016021
C:integral to membrane
GO:0005886
C:plasma membrane
GO:0005524
F:ATP binding
GO:0008551
F:cadmium-exporting ATPase activity
GO:0005261
F:cation channel activity
GO:0046872
F:metal ion binding
GO:0016463
F:zinc-exporting ATPase activity
GO:0006754
P:ATP biosynthetic process
GO:0030001
P:metal ion transport
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References (4)[1] “Cloning and membrane topology of a P type ATPase from Helicobacter pylori.” Melchers K.et.al. 8550601 [2] “The complete genome sequence of the gastric pathogen Helicobacter pylori.” Tomb J.-F.et.al. 9252185 [3] “Helicobacter pylori cadA encodes an essential Cd(II)-Zn(II)-Co(II) resistance factor influencing urease activity.” Herrmann L.et.al. 10417643 [4] “Membrane topology of CadA homologous P-type ATPase of Helicobacter pylori as determined by expression of phoA fusions in Escherichia coli and the positive inside rule.” Melchers K.et.al. 10577484
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MQEYHIHNLD CPDCASKLER DLNELDYVKK AQINFSTSKL FLDTSDFEKV KAFIKQNEPH 61: LSLSFKEATE KPLSFTPLII TIMVFLGAIL ILHLNPSPLI EKAMFFVLAL VYLVSGKDVI 121: LGAFRGLRKG QFFDENALML IATIAAFFVG AYEESVSIMV FYSAGEFLQK LAVSRSKKSL 181: KALVDVAPNL AYLKKGDELV SVAPEDLRVN DIVVVKVGEK VPVDGVVVKG ESLLDERALS 241: GESMPVNVSE NSKVLGGSLN LKAVLEIQVE KMYKDSSIAK VVDLVQQATN EKSETEKFIT 301: KFSRYYTPSV LFIALMIAVL PPLFSMGSFD EWIYRGLVAL MVSCPCALVI SVPLGYFGGV 361: GAASRKGILM KGVHVLEVLT QAKSIAFDKT GTLTKGVFKV TDIVPQNGHS KEEVLHYASC 421: SQLLSTHPIA LSIQKACEEM LKDDKHQHDI KNYEEVSGMG VKAQCHTDLI IAGNEKMLDQ 481: FHIAHSPSKE NGTIVHVAFN QTYVGYIVIS DEIKDDAIEC LRDLKVQGIE NFCILSGDRK 541: SATESIAQTL GCEYHASLLP EEKTSVFKTF KERYKAPAIF VGDGINDAPT LASADVGIGM 601: GKGSELSKQS ADIVITNDSL NSLVKVLAIA KKTKSIIWQN ILFALGIKAV FIVLGLMGVA 661: SLWEAVFGDV GVTLLALANS MRAMRA