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| Accession Number: | Q6VXY9 |
| Protein Name: | Putative miltefosine transporter aka MIL |
| Length: | 1097 |
| Molecular Weight: | 124113.00 |
| Species: | Leishmania donovani [5661] |
| Number of TMSs: | 9 |
| Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
| Substrate | phospholipid, glycerophospholipid, miltefosine |
Cross database links:
| Pfam: | PF00122 PF00702 |
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Gene Ontology
GO:0016021
C:integral to membrane
GO:0005524
F:ATP binding
GO:0015662
F:ATPase activity, coupled to transmembrane m...
GO:0000287
F:magnesium ion binding
GO:0004012
F:phospholipid-translocating ATPase activity
GO:0006754
P:ATP biosynthetic process
GO:0015914
P:phospholipid transport
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References (1)[1] “Functional cloning of the miltefosine transporter. A novel P-type phospholipid translocase from Leishmania involved in drug resistance.” Perez-Victoria F.J.et.al. 14514670
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MPNQPPCWRK CLSTRIFPDK LSKSFCCFSA EADVDEDDEV IVYLNDPELN AQFNYPSNFI 61: RTSKYTLISF LPLSLLLEFK KVSNLYFLMN VIFSLIPGVS PLSPATSIAP LSFVLIVALI 121: KEGVEDIKRH QADNRANSIL VQVLRNGKLV SVHSKDIHPG DVMRIKNGEE VRADVVMLAS 181: SVEEGQAFID TCNLDGETNL KSRKALEATW ALCEVEAIMN STAVLHTSKP DPGLLSWAGL 241: LEINGEEHAL SLNQFLYRGC VLRNTDWVWG MVAYAGVDTK LFRNLKPKPP KSSNLDRKLN 301: YFIIAILIFQ NIMLFILASM AVWWNSKYRE TPYLRFFISF RKNVTLWGYR YLSYFILLSY 361: CVPISLFITI EVCKVVQAQW MRVDCLMMEY MSNRWRHCQP NTSNLNEQLA MVRFIFSDKT 421: GTLTENVMKF KLGDALGNPI DADNLDECIA QLRKEAESKG LGPLQEYFLA LALCNTVQPF 481: KDDTDDLGVV YEGSSPDEVA LVETAAAVGY RLISRTTKSI TLLLHDGTRK VYNILATLEF 541: TPDRKMMSII VEDSDTKKIT LYNKGADSFI RPQLSRAPDV QGHIENVEIP LTEMSSSGLR 601: TLLVCAKDIT RRQFDPWFEK FVEAGKSLHN RSSNIDKVCL EMEQDMRLVG ATAIEDKLQD 661: EVPETLSFFL SAGVIIWMLT GDKRETAVTI AATSTLCDPR NDFIDHIDIG HLNSSDPKAI 721: ERVGRDLEVV EQHIALKGTH KERRCTLVID GPALNIAMEH YFDQFLRLSH QVNSAVCCRL 781: TPIQKATVVR MFQKSTGKTA LAIGDGANDV SMIREGRVGV GIIGLEGAHA ALAADYAIPR 841: FKHLRRLCAV HGRYSLFRNA SCILVSFHKN ITVSVVQFIF AFYVGFSGLT LFDGWMLTFY 901: NVLLTSIPPF FMGIFDKDLP EDALLERPKL YTPLSHGEYF NLATLLRWFV ESLTTAVILF 961: YAAYPTLIRQ DGSHQRYTGG ETGTLVFSGL ILVIQTRFIL QIRYWQWLQV FGMAMSIFLF 1021: LLLFLVYSAI PSVFSDTNFY YQAFDLMSTA KYWFFLLLYV GTEVVVVLGV MTFQKNLFPT 1081: LRDVAERQYA VQNGGKL