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3.D.1.1.1
NADH dehydrogenase I, NuoA-N.  NuoL probably comprises part of the proton pathway (Nakamaru-Ogiso et al. 2010).  NuoL (ND5), NuoM (ND4) and NuoN (ND2) are all homologous to proton:sodium antiporters and may all play reoles in pumping protons using a similar mechanism (Sato et al. 2013).

Accession Number:P31979
Protein Name:NUOF aka B2284
Length:445
Molecular Weight:49292.00
Species:Escherichia coli [83333]
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Peripheral membrane protein2 / Cytoplasmic side3
Substrate hydron

Cross database links:

DIP: DIP-10382N
RefSeq: AP_002882.1    NP_416787.1   
Entrez Gene ID: 946753   
Pfam: PF01512    PF10589    PF10531   
BioCyc: EcoCyc:NUOF-MONOMER    ECOL168927:B2284-MONOMER    MetaCyc:NUOF-MONOMER   
KEGG: ecj:JW2279    eco:b2284   

Gene Ontology

GO:0045272 C:plasma membrane respiratory chain complex I
GO:0051539 F:4 iron, 4 sulfur cluster binding
GO:0010181 F:FMN binding
GO:0046872 F:metal ion binding
GO:0051287 F:NAD or NADH binding
GO:0008137 F:NADH dehydrogenase (ubiquinone) activity
GO:0048038 F:quinone binding
GO:0009060 P:aerobic respiration
GO:0009061 P:anaerobic respiration
GO:0055114 P:oxidation reduction

References (7)

[1] “The gene locus of the proton-translocating NADH: ubiquinone oxidoreductase in Escherichia coli. Organization of the 14 genes and relationship between the derived proteins and subunits of mitochondrial complex I.”  Weidner U.et.al.   7690854
[2] “Mutations in NADH:ubiquinone oxidoreductase of Escherichia coli affect growth on mixed amino acids.”  Pruss B.M.et.al.   8157582
[3] “Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features.”  Yamamoto Y.et.al.   9205837
[4] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[5] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[6] “Escherichia coli mutants lacking NADH dehydrogenase I have a competitive disadvantage in stationary phase.”  Zambrano M.M.et.al.   8366049
[7] “Isolation and characterization of the proton-translocating NADH: ubiquinone oxidoreductase from Escherichia coli.”  Leif H.et.al.   7607227

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKNIIRTPET HPLTWRLRDD KQPVWLDEYR SKNGYEGARK ALTGLSPDEI VNQVKDAGLK 
61:	GRGGAGFSTG LKWSLMPKDE SMNIRYLLCN ADEMEPGTYK DRLLMEQLPH LLVEGMLISA 
121:	FALKAYRGYI FLRGEYIEAA VNLRRAIAEA TEAGLLGKNI MGTGFDFELF VHTGAGRYIC 
181:	GEETALINSL EGRRANPRSK PPFPATSGAW GKPTCVNNVE TLCNVPAILA NGVEWYQNIS 
241:	KSKDAGTKLM GFSGRVKNPG LWELPFGTTA REILEDYAGG MRDGLKFKAW QPGGAGTDFL 
301:	TEAHLDLPME FESIGKAGSR LGTALAMAVD HEINMVSLVR NLEEFFARES CGWCTPCRDG 
361:	LPWSVKILRA LERGEGQPGD IETLEQLCRF LGPGKTFCAH APGAVEPLQS AIKYFREEFE 
421:	AGIKQPFSNT HLINGIQPNL LKERW