3.D.4.3.5
Cytochrome bd, AppB (CbdB, CyxB) of 378 aas and 9 TMSs. It is a terminal oxidase that catalyzes quinol-dependent, Na+-independent oxygen uptake. It prefers menadiol over other quinols although ubiquinol was not tested (Sturr et al. 1996). It generates a proton motive force using protons and electrons from opposite sides of the membrane to generate H2O, transferring 1 proton/electron. The mechanism of generation of a transmembrane electric potential difference (Deltapsi) during the catalytic cycle of a bd-type triheme terminal quinol oxidase hasbeen reviewed (Borisov 2023).
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| Accession Number: | P26458 |
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| Protein Name: | Cytochrome bd-II ubiquinol oxidase subunit 2 |
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| Length: | 378 |
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| Molecular Weight: | 42424.00 |
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| Species: | Escherichia coli (strain K12) [83333] |
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| Number of TMSs: | 9 |
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| Location1 / Topology2 / Orientation3: |
Cell inner membrane1 / Multi-pass membrane protein2 |
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| Substrate |
hydron, electron |
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1: MFDYETLRFI WWLLIGVILV VFMISDGFDM GIGCLLPLVA RNDDERRIVI NSVGAHWEGN
61: QVWLILAGGA LFAAWPRVYA AAFSGFYVAM ILVLCSLFFR PLAFDYRGKI ADARWRKMWD
121: AGLVIGSLVP PVVFGIAFGN LLLGVPFAFT PQLRVEYLGS FWQLLTPFPL LCGLLSLGMV
181: ILQGGVWLQL KTVGVIHLRS QLATKRAALL VMLCFLLAGY WLWVGIDGFV LLAQDANGPS
241: NPLMKLVAVL PGAWMNNFVE SPVLWIFPLL GFFCPLLTVM AIYRGRPGWG FLMASLMQFG
301: VIFTAGITLF PFVMPSSVSP ISSLTLWDST SSQLTLSIML VIVLIFLPIV LLYTLWSYYK
361: MWGRMTTETL RRNENELY