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4.A.1.1.11
The glucose/maltose/maltotriose porter, MalT or PtsG (31% identical to 4.A.1.1.9) (Webb et al., 2007).  Lactoperoxidase (LPO) shows promise in the prevention of dental caries. It has antimicrobial properties and is part of the non-specific antimicrobial immune system. A thiocyanate-iodide mixture strongly inhibited glucose and sucrose consumption as well as transmembrane PTS glucose transport. Thus, the LPO-iodide system had a strong inhibitory effect on biofilm growth and lactate synthesis (complete inhibition) (Magacz et al. 2023).

Accession Number:Q8DS05
Protein Name:MalT IICBA
Length:729
Molecular Weight:78416.00
Species:Streptococcus mutans [1309]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate maltose, alpha-maltotriose, D-glucopyranose

Cross database links:

RefSeq: NP_722340.1   
Entrez Gene ID: 1029230   
Pfam: PF00358    PF00367    PF02378   
BioCyc: SMUT210007:SMU_2047-MONOMER   
KEGG: smu:SMU.2047   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0016301 F:kinase activity
GO:0008982 F:protein-N(PI)-phosphohistidine-sugar phosph...
GO:0005351 F:sugar:hydrogen symporter activity
GO:0009401 P:phosphoenolpyruvate-dependent sugar phospho...

References (1)

[1] “Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen.”  Ajdic D.J.et.al.   12397186

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKNYKQLFSF EFWQKFGKCL MVVIAVMPAA GLMVSIGNSL ALIDPKSTLL VTVANIIAQI 
61:	GWGVINNLHI LFAVAIGGSW AKERAGGAFA AALAFILINL ITGNFYGISL EMIADKTSYV 
121:	HNIFGGKMHV ADYFINVLGQ PALNMGVFVG IISGFVGATA YNKYYNFRKL PDVLSFFNGK 
181:	RFVPFVVIVR STIVALILSV FWPIVQSGIN GFGMWIASSQ HTAPFLAPFL YGTLERLLLP 
241:	FGLHHMLTIP MNYTQLGGTY VVLTGAQAGK HVLGQDPLWL AWVQDLIHLK GAGHMSQYHH 
301:	LLTSVTPARF KVGQMIGSSG ILMGLTLAMY RNVDPDKKEK YKGMFLSAAV AVFLTGVTEP 
361:	LEYMFMFAAL PLYLVYAVVQ GLAFASADLI HLRVHSFGNI EFLTRTPMAI KAGLAMDIVN 
421:	FIVVSVVFGV AMYFITNFMI KKFNLATSGR NGNYDTGDDA SDETASNSNA GTANANSQIV 
481:	KIINLLGGKE NISDVDACMT RLRITVTDVA KVGDEAAWKK AGAMGLIVKG NGVQAVYGPK 
541:	ADVLKSDIQD LLDSGVDIPK TDVTALEEDK TADVSFKGVT EEIATVADGQ VLPITQVHDP 
601:	VFSQKMMGDG FAVEPENGNI YSPVAGLVTS VFPTKHALGL LTDDGLEVLV HVGLDTVALN 
661:	GAPFSAKVKD GQRVALGDLL LVADLEAIKS ADRETTVIVA FTNTAELKSV TLEKTGQQAA 
721:	KTVVAKVEL