4.A.6.1.16 Constitutively synthesized (at a low level) sensor, MpoABCD, controlling expression of the man operon-encoding the ManLMN (MptACD) transport system (see TC# 4.A.6.1.15). The Mpo system interacts with and phosphorylates ManR, the transcriptional regulator of the man operon (Aké et al. 2011). This system is a mannose PTS system, IIABCDMan or MpoABCD that transports its
sugar substrates slowly and serves as a glucose (sugar substrate) sensor to regulate the
activity of ManR by a phosphorylation/dephosphorylation mechanism. MptACD (TC# 4.A.6.1.15) is
the primary
inducible sugar transport system. ManR is an activator that is inactivated by a
phosphorylation/dephosphorylation mechanism (Aké et al. 2011; Zébré et al. 2015).
|
Accession Number: | Q8Y8W0 |
Protein Name: | Lmo0782 protein |
Length: | 270 |
Molecular Weight: | 28202.00 |
Species: | Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) [169963] |
Number of TMSs: | 8 |
Substrate |
mannose |
---|
1: MSAIQLILVF LVSCISGMGS ILDEWQTHRP LIACTLIGLV LGDITTGIII GGTLEMIALG
61: WMNIGAAVAP DAALASIIST ILVITGGQDI SVGISLAIPL AALGQVLTIL VRTITVAFQH
121: MADKAGKEGN LRSLDWIHVT ALLLQAMRIA IPAVIVAVTV GTSAVENLLN AIPDVIVNGL
181: NVAGGFIVVV GYAMVINMMS AKYLMPFFFL GFVVAAFTQF NLVALGVLGL VAAIIYIQLN
241: PKYQLKEAIQ QYGGGGGGRS ADDLDDDLDD