4.A.6.1.16
Constitutively synthesized (at a low level) sensor, MpoABCD, controlling expression of the man operon-encoding the ManLMN (MptACD) transport system (see TC# 4.A.6.1.15). The Mpo system interacts with and phosphorylates ManR, the transcriptional regulator of the man operon (Aké et al. 2011). This system is a mannose PTS system, IIABCD^Man or MpoABCD that transports its sugar substrates slowly and serves as a glucose (sugar substrate) sensor to regulate the activity of ManR by a phosphorylation/dephosphorylation mechanism. MptACD (TC# 4.A.6.1.15) is the primary inducible sugar transport system. ManR is an activator that is inactivated by a phosphorylation/dephosphorylation mechanism (Aké et al. 2011; Zébré et al. 2015).