4.C.1.1.16
Bifunctional protein, Aas of 719 aas and 3 - 5 TMSs. Plays a role in lysophospholipid acylation.
Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP
intermediate in the presence of ATP and magnesium. Its physiological
function is to regenerate phosphatidylethanolamine from
2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by
transacylation reactions or degradation by phospholipase A1.
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| Accession Number: | P31119 |
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| Protein Name: | Bifunctional protein Aas |
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| Length: | 719 |
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| Molecular Weight: | 80700.00 |
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| Species: | Escherichia coli (strain K12) [83333] |
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| Number of TMSs: | 5 |
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| Location1 / Topology2 / Orientation3: |
Cell inner membrane1 / Multi-pass membrane protein2 |
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| Substrate |
fatty acid |
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1: MLFSFFRNLC RVLYRVRVTG DTQALKGERV LITPNHVSFI DGILLGLFLP VRPVFAVYTS
61: ISQQWYMRWL KSFIDFVPLD PTQPMAIKHL VRLVEQGRPV VIFPEGRITT TGSLMKIYDG
121: AGFVAAKSGA TVIPVRIEGA ELTHFSRLKG LVKRRLFPQI TLHILPPTQV AMPDAPRARD
181: RRKIAGEMLH QIMMEARMAV RPRETLYESL LSAMYRFGAG KKCVEDVNFT PDSYRKLLTK
241: TLFVGRILEK YSVEGERIGL MLPNAGISAA VIFGAIARRR MPAMMNYTAG VKGLTSAITA
301: AEIKTIFTSR QFLDKGKLWH LPEQLTQVRW VYLEDLKADV TTADKVWIFA HLLMPRLAQV
361: KQQPEEEALI LFTSGSEGHP KGVVHSHKSI LANVEQIKTI ADFTTNDRFM SALPLFHSFG
421: LTVGLFTPLL TGAEVFLYPS PLHYRIVPEL VYDRSCTVLF GTSTFLGHYA RFANPYDFYR
481: LRYVVAGAEK LQESTKQLWQ DKFGLRILEG YGVTECAPVV SINVPMAAKP GTVGRILPGM
541: DARLLSVPGI EEGGRLQLKG PNIMNGYLRV EKPGVLEVPT AENVRGEMER GWYDTGDIVR
601: FDEQGFVQIQ GRAKRFAKIA GEMVSLEMVE QLALGVSPDK VHATAIKSDA SKGEALVLFT
661: TDNELTRDKL QQYAREHGVP ELAVPRDIRY LKQMPLLGSG KPDFVTLKSW VDEAEQHDE