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| Accession Number: | P69451 |
| Protein Name: | Long-chain-fatty-acid--CoA ligase LCFA aka FadD aka OLDD aka B1805 |
| Length: | 561 |
| Molecular Weight: | 62332.00 |
| Species: | Escherichia coli [83333] |
| Number of TMSs: | 2 |
| Location1 / Topology2 / Orientation3: | Membrane1 / Peripheral membrane protein2 |
| Substrate | fatty acid |
Cross database links:
| RefSeq: | AP_002424.1 NP_416319.1 |
|---|---|
| Entrez Gene ID: | 946327 |
| Pfam: | PF00501 PF13193 |
| BioCyc: | EcoCyc:ACYLCOASYN-MONOMER ECOL168927:B1805-MONOMER MetaCyc:ACYLCOASYN-MONOMER |
| KEGG: | ecj:JW1794 eco:b1805 eco:b1805 |
Gene Ontology
GO:0005829
C:cytosol
GO:0009898
C:internal side of plasma membrane
GO:0005524
F:ATP binding
GO:0004467
F:long-chain-fatty-acid-CoA ligase activity
GO:0070538
F:oleic acid binding
GO:0006637
P:acyl-CoA metabolic process
GO:0006635
P:fatty acid beta-oxidation
GO:0008654
P:phospholipid biosynthetic process
GO:0004467
F:long-chain fatty acid-CoA ligase activity
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References (12)[1] “The fadD gene of Escherichia coli K12 is located close to rnd at 39.6 min of the chromosomal map and is a new member of the AMP-binding protein family.” Fulda M.et.al. 8107670 [2] “Cloning, sequencing, and expression of the fadD gene of Escherichia coli encoding acyl coenzyme A synthetase.” Black P.N.et.al. 1460045 [3] “A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map.” Itoh T.et.al. 9097040 [4] “The complete genome sequence of Escherichia coli K-12.” Blattner F.R.et.al. 9278503 [5] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.” Hayashi K.et.al. 16738553 [6] “Functional role of fatty acyl-coenzyme A synthetase in the transmembrane movement and activation of exogenous long-chain fatty acids. Amino acid residues within the ATP/AMP signature motif of Escherichia coli FadD are required for enzyme activity and fatty acid transport.” Weimar J.D.et.al. 12034706 [7] “The fadD gene of Escherichia coli K12 is located close to rnd at 39.6 min of the chromosomal map and is a new member of the AMP-binding protein family.” Fulda M.et.al. 8107670 [8] “Cloning, sequencing, and expression of the fadD gene of Escherichia coli encoding acyl coenzyme A synthetase.” Black P.N.et.al. 1460045 [9] “A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map.” Itoh T.et.al. 9097040 [10] “The complete genome sequence of Escherichia coli K-12.” Blattner F.R.et.al. 9278503 [11] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.” Hayashi K.et.al. 16738553 [12] “Functional role of fatty acyl-coenzyme A synthetase in the transmembrane movement and activation of exogenous long-chain fatty acids. Amino acid residues within the ATP/AMP signature motif of Escherichia coli FadD are required for enzyme activity and fatty acid transport.” Weimar J.D.et.al. 12034706
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MKKVWLNRYP ADVPTEINPD RYQSLVDMFE QSVARYADQP AFVNMGEVMT FRKLEERSRA 61: FAAYLQQGLG LKKGDRVALM MPNLLQYPVA LFGILRAGMI VVNVNPLYTP RELEHQLNDS 121: GASAIVIVSN FAHTLEKVVD KTAVQHVILT RMGDQLSTAK GTVVNFVVKY IKRLVPKYHL 181: PDAISFRSAL HNGYRMQYVK PELVPEDLAF LQYTGGTTGV AKGAMLTHRN MLANLEQVNA 241: TYGPLLHPGK ELVVTALPLY HIFALTINCL LFIELGGQNL LITNPRDIPG LVKELAKYPF 301: TAITGVNTLF NALLNNKEFQ QLDFSSLHLS AGGGMPVQQV VAERWVKLTG QYLLEGYGLT 361: ECAPLVSVNP YDIDYHSGSI GLPVPSTEAK LVDDDDNEVP PGQPGELCVK GPQVMLGYWQ 421: RPDATDEIIK NGWLHTGDIA VMDEEGFLRI VDRKKDMILV SGFNVYPNEI EDVVMQHPGV 481: QEVAAVGVPS GSSGEAVKIF VVKKDPSLTE ESLVTFCRRQ LTGYKVPKLV EFRDELPKSN 541: VGKILRRELR DEARGKVDNK A