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|---|---|
| Accession Number: | Q6PCB7 |
| Protein Name: | Long-chain fatty acid transport protein 1 |
| Length: | 646 |
| Molecular Weight: | 71108.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 1 |
| Location1 / Topology2 / Orientation3: | Cell membrane1 / Single-pass membrane protein2 |
| Substrate | fatty acid |
Cross database links:
| Entrez Gene ID: | 376497 |
|---|---|
| Pfam: | PF00501 |
| KEGG: | hsa:376497 hsa:376497 |
Gene Ontology
GO:0012505
C:endomembrane system
GO:0016021
C:integral to membrane
GO:0000166
F:nucleotide binding
GO:0032049
P:cardiolipin biosynthetic process
GO:0006631
P:fatty acid metabolic process
GO:0015909
P:long-chain fatty acid transport
GO:0071072
P:negative regulation of phospholipid biosynthetic process
GO:0006654
P:phosphatidic acid biosynthetic process
GO:0006656
P:phosphatidylcholine biosynthetic process
GO:0006646
P:phosphatidylethanolamine biosynthetic process
GO:0006661
P:phosphatidylinositol biosynthetic process
GO:0006659
P:phosphatidylserine biosynthetic process
GO:0055085
P:transmembrane transport
GO:0005901
C:caveola
GO:0005783
C:endoplasmic reticulum
GO:0005792
C:microsome
GO:0005743
C:mitochondrial inner membrane
GO:0005886
C:plasma membrane
GO:0015245
F:fatty acid transporter activity
GO:0031957
F:very long-chain fatty acid-CoA ligase activity
GO:0033211
P:adiponectin-mediated signaling pathway
GO:0031652
P:positive regulation of heat generation
GO:0071902
P:positive regulation of protein serine/threonine kinase activity
GO:0009409
P:response to cold
GO:0032868
P:response to insulin stimulus
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References (8)[1] “The DNA sequence and biology of human chromosome 19.” Grimwood J.et.al. 15057824 [2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [3] “The human fatty acid transport protein-1 (SLC27A1; FATP-1) cDNA and gene: organization, chromosomal localization, and expression.” Martin G.et.al. 10873384 [4] “FATP1 channels exogenous FA into 1,2,3-triacyl-sn-glycerol and down-regulates sphingomyelin and cholesterol metabolism in growing 293 cells.” Hatch G.M.et.al. 12235169 [5] “The DNA sequence and biology of human chromosome 19.” Grimwood J.et.al. 15057824 [6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [7] “The human fatty acid transport protein-1 (SLC27A1; FATP-1) cDNA and gene: organization, chromosomal localization, and expression.” Martin G.et.al. 10873384 [8] “FATP1 channels exogenous FA into 1,2,3-triacyl-sn-glycerol and down-regulates sphingomyelin and cholesterol metabolism in growing 293 cells.” Hatch G.M.et.al. 12235169
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MRAPGAGAAS VVSLALLWLL GLPWTWSAAA ALGVYVGSGG WRFLRIVCKT ARRDLFGLSV 61: LIRVRLELRR HQRAGHTIPR IFQAVVQRQP ERLALVDAGT GECWTFAQLD AYSNAVANLF 121: RQLGFAPGDV VAIFLEGRPE FVGLWLGLAK AGMEAALLNV NLRREPLAFC LGTSGAKALI 181: FGGEMVAAVA EVSGHLGKSL IKFCSGDLGP EGILPDTHLL DPLLKEASTA PLAQIPSKGM 241: DDRLFYIYTS GTTGLPKAAI VVHSRYYRMA AFGHHAYRMQ AADVLYDCLP LYHSAGNIIG 301: VGQCLIYGLT VVLRKKFSAS RFWDDCIKYN CTVVQYIGEI CRYLLKQPVR EAERRHRVRL 361: AVGNGLRPAI WEEFTERFGV RQIGEFYGAT ECNCSIANMD GKVGSCGFNS RILPHVYPIR 421: LVKVNEDTME LLRDAQGLCI PCQAGEPGLL VGQINQQDPL RRFDGYVSES ATSKKIAHSV 481: FSKGDSAYLS GDVLVMDELG YMYFRDRSGD TFRWRGENVS TTEVEGVLSR LLGQTDVAVY 541: GVAVPGVEGK AGMAAVADPH SLLDPNAIYQ ELQKVLAPYA RPIFLRLLPQ VDTTGTFKIQ 601: KTRLQREGFD PRQTSDRLFF LDLKQGHYLP LNEAVYTRIC SGAFAL