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4.C.2.1.1
Peroxisomal carnitine O-acetyl transferase (carnitine acylase (CAT or CrAT))

Accession Number:P43155
Protein Name:CrAT or CAT1
Length:626
Molecular Weight:70858.00
Species:Homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Peroxisome1
Substrate

Cross database links:

RefSeq: NP_000746.2   
Entrez Gene ID: 1384   
Pfam: PF00755   
OMIM: 600184  gene
KEGG: hsa:1384   

Gene Ontology

GO:0005783 C:endoplasmic reticulum
GO:0005743 C:mitochondrial inner membrane
GO:0005777 C:peroxisome
GO:0004092 F:carnitine O-acetyltransferase activity
GO:0015980 P:energy derivation by oxidation of organic c...
GO:0033540 P:fatty acid beta-oxidation using acyl-CoA ox...
GO:0006810 P:transport

References (7)

[1] “DNA sequence and analysis of human chromosome 9.”  Humphray S.J.et.al.   15164053
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “Divergent sequences in the 5' region of cDNA suggest alternative splicing as a mechanism for the generation of carnitine acetyltransferases with different subcellular localizations.”  Corti O.et.al.   7945262
[4] “Molecular cloning of cDNAs encoding human carnitine acetyltransferase and mapping of the corresponding gene to chromosome 9q34.1.”  Corti O.et.al.   7829107
[5] “Lysine acetylation targets protein complexes and co-regulates major cellular functions.”  Choudhary C.et.al.   19608861
[6] “Structure of human carnitine acetyltransferase. Molecular basis for fatty acyl transfer.”  Wu D.et.al.   12562770
[7] “Structural and mutational characterization of L-carnitine binding to human carnitine acetyltransferase.”  Govindasamy L.et.al.   15099582
Structure:
1NM8   1S5O     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MLAFAARTVV KPLGFLKPFS LMKASSRFKA HQDALPRLPV PPLQQSLDHY LKALQPIVSE 
61:	EEWAHTKQLV DEFQASGGVG ERLQKGLERR ARKTENWLSE WWLKTAYLQY RQPVVIYSSP 
121:	GVMLPKQDFV DLQGQLRFAA KLIEGVLDFK VMIDNETLPV EYLGGKPLCM NQYYQILSSC 
181:	RVPGPKQDTV SNFSKTKKPP THITVVHNYQ FFELDVYHSD GTPLTADQIF VQLEKIWNSS 
241:	LQTNKEPVGI LTSNHRNSWA KAYNTLIKDK VNRDSVRSIQ KSIFTVCLDA TMPRVSEDVY 
301:	RSHVAGQMLH GGGSRLNSGN RWFDKTLQFI VAEDGSCGLV YEHAAAEGPP IVTLLDYVIE 
361:	YTKKPELVRS PLVPLPMPKK LRFNITPEIK SDIEKAKQNL SIMIQDLDIT VMVFHHFGKD 
421:	FPKSEKLSPD AFIQMALQLA YYRIYGQACA TYESASLRMF HLGRTDTIRS ASMDSLTFVK 
481:	AMDDSSVTEH QKVELLRKAV QAHRGYTDRA IRGEAFDRHL LGLKLQAIED LVSMPDIFMD 
541:	TSYAIAMHFH LSTSQVPAKT DCVMFFGPVV PDGYGVCYNP MEAHINFSLS AYNSCAETNA 
601:	ARLAHYLEKA LLDMRALLQS HPRAKL